2. Gene
  3. PDE1A - phosphodiesterase 1A Gene

PDE1A - phosphodiesterase 1A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 1A

种属: Homo sapiens

同用名: HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A

基因 ID: 5136 | 基因类型: protein coding

关于 PDE1A

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,140,041-182,716,797 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 20 paralogues. Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues.

功能概要

环核苷酸磷酸二酯酶 (PDE) 通过将 cAMP 和/或 cGMP 水解成各自的核苷 5-主要单磷酸来调节细胞内环核苷酸浓度，从而在信号转导中发挥作用。 PDE1 家族的成员，例如 PDE1A，是 CA (2+) /钙调蛋白 (参见 CALM1；MIM 114180) 依赖性 PDE (CaM-PDE) ，在 CA (2+) 存在的情况下被钙调蛋白激活 (Michibata 等 al., 2001 [PubMed 11342109]；Fidock 等人，2002 [PubMed 11747989]) .[OMIM 提供，2009 年 10 月]

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are CA(2+)/Calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by Calmodulin in the presence of CA(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

PDE1A 基因产物(25)

mRNA Protein Name
NM_001395269.1 NP_001382198.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 11
NM_001395265.2 NP_001382194.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 8
NM_001258313.3 NP_001245242.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 4
XM_017004294.3 XP_016859783.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2
NM_001395259.2 NP_001382188.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395266.1 NP_001382195.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_001258314.3 NP_001245243.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 5
XM_011511324.4 XP_011509626.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3
XM_047444688.1 XP_047300644.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4
XM_011511325.4 XP_011509627.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5
NM_001395260.2 NP_001382189.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395262.1 NP_001382191.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395267.1 NP_001382196.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_005019.7 NP_005010.2 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395264.1 NP_001382193.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7
NM_001395268.1 NP_001382197.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 10
NM_001003683.3 NP_001003683.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395261.2 NP_001382190.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001258312.3 NP_001245241.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3
XM_011511326.3 XP_011509628.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6
XM_011511323.3 XP_011509625.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1
XR_007076388.1
NM_001395258.2 NP_001382187.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395263.1 NP_001382192.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001363871.4 NP_001350800.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
8557689 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE1A 蛋白结构

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (73 - 133)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (218 - 446)

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  • 535 a.a.
蛋白主名 其他名称

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

61 kDa Cam-PDE

calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase

phosphodiesterase 1A, calmodulin-dependent

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-12501A ITI-214 Inhibitor 99.19% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% 否
HY-136569 DSR-141562 Inhibitor 99.98% 否
HY-147946 PDE1-IN-4 Inhibitor / 否
HY-RS10208 PDE1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-120741 PF-04822163 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PDE1A VGNC VGNC:44348
Mus musculus PDE1A MGD MGI:1201792
Rattus norvegicus PDE1A RGD RGD:68329
Macaca mulatta PDE1A VGNC VGNC:75909
Bos taurus PDE1A VGNC VGNC:32671
Felis catus PDE1A VGNC VGNC:68752
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