2. Gene
  3. TRMT112 - tRNA methyltransferase activator subunit 11-2 Gene

TRMT112 - tRNA methyltransferase activator subunit 11-2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tRNA 甲基转移酶激活子亚基 11-2

种属: Homo sapiens

同用名: TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2

基因 ID: 51504 | 基因类型: protein coding

关于 TRMT112

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,316,460-64,318,596 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues.

功能概要

启用蛋白质异二聚化活性和蛋白质甲基转移酶活性。参与大分子甲基化和 rRNA 加工的正调控。位于细胞质的核质和核周区。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TRMT112 基因产物(5)

mRNA Protein Name
NM_001286082.2 NP_001273011.1 multifunctional methyltransferase subunit TRM112-like protein isoform 2
NM_001286084.2 NP_001273013.1 multifunctional methyltransferase subunit TRM112-like protein isoform 3
NM_001372071.1 NP_001359000.1 multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_001372072.1 NP_001359001.1 multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_016404.3 NP_057488.1 multifunctional methyltransferase subunit TRM112-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18539146 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
25851604 GOA
enables protein methyltransferase activity IDA
IDA: 通过直接分析推断
18539146 GOA
enables tRNA methyltransferase activator activity IDA
IDA: 通过直接分析推断
34669960 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-glutamine methylation IDA
IDA: 通过直接分析推断
18539146 GOA
involved in positive regulation of rRNA processing IMP
IMP: 通过突变表型推断
25851604 GOA
involved in rRNA (guanine-N7)-methylation IMP
IMP: 通过突变表型推断
25851604 GOA
involved in rRNA methylation IDA
IDA: 通过直接分析推断
31328227 GOA
involved in tRNA methylation IMP
IMP: 通过突变表型推断
34669960 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: 通过直接分析推断
31061526 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleoplasm IDA
IDA: 通过直接分析推断
25851604 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
25851604 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
18539146 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRMT112 蛋白结构

Trm112p

Trm112p: Trm112p-like protein (2 - 112)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

multifunctional methyltransferase subunit TRM112-like protein

TRM112-like protein

TRMT112 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRMT112 Q9UI30 BUD23 Homo sapiens O43709
Pull Down
25851604
种属内
TRMT112 Q9UI30 BUD23 Homo sapiens O43709
Y2H Array
32296183
种属内
TRMT112 Q9UI30 BUD23 Homo sapiens O43709
Y2H Prey Pooling
32296183
种属内
TRMT112 Q9UI30 BUD23 Homo sapiens O43709
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 ALKBH8 Homo sapiens Q96BT7
Y2H
20123966
种属内
TRMT112 Q9UI30 ALKBH8 Homo sapiens Q96BT7
Pull Down
20123966
种属内
TRMT112 Q9UI30 ALKBH8 Homo sapiens Q96BT7
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 METTL5 Homo sapiens Q9NRN9
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 THUMPD2 Homo sapiens Q9BTF0
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
TRMT112 Q9UI30 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
TRMT112 Q9UI30 TRMT11 Homo sapiens Q7Z4G4
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 THUMPD3 Homo sapiens Q9BV44
Y2H Array
32296183
种属内
TRMT112 Q9UI30 THUMPD3 Homo sapiens Q9BV44
Anti Tag CoIP
34948388
种属内
TRMT112 Q9UI30 THUMPD3 Homo sapiens Q9BV44
Y2H Prey Pooling
32296183
种属内
TRMT112 Q9UI30 N6AMT1 Homo sapiens Q9Y5N5
Pull Down
25851604
种属内
TRMT112 Q9UI30 N6AMT1 Homo sapiens Q9Y5N5
Anti Tag CoIP
34948388
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TRMT112 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71644 TRMT112 Protein, Human (His-SUMO) Q9UI30-1 (M1-S125) ≥95%

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15090 TRMT112 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRMT112 VGNC VGNC:101420
Canis familiaris TRMT112 VGNC VGNC:47855
Felis catus TRMT112 VGNC VGNC:81099
Mus musculus TRMT112 MGD MGI:1914924
Rattus norvegicus TRMT112 RGD RGD:1309710
Others TRMT112 NCBI
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