LARS1 - leucyl-tRNA synthetase 1 Gene

中文名称：亮氨酰 tRNA 合成酶 1

种属: Homo sapiens

同用名: LRS; LARS; LEUS; LFIS; ILFS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl

基因 ID: 51520 | 基因类型: protein coding

关于 LARS1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,113,034-146,182,650 (from NCBI)

This gene has 32 transcripts (splice variants), 207 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 24.0), brain (RPKM 19.6) and 25 other tissues.

功能概要

该基因编码胞质亮氨酸-tRNA 合成酶，是 I 类氨酰-tRNA 合成酶家族的成员。编码的酶催化 L-亮氨酸与 tRNA (Leu) 的 ATP 依赖性连接。它作为多合成酶复合物的一部分存在于细胞质中，并通过其 C 末端结构域与精氨酸 tRNA 合成酶相互作用。在患有婴儿肝衰竭综合征 1 的受影响个体中发现了该基因的突变。已经观察到该基因的选择性剪接转录物变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I Aminoacyl-tRNA Synthetase family. The encoded Enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]

LARS1 基因产物(4)

mRNA	Protein	Name
NM_001317964.2	NP_001304893.1	leucine--tRNA ligase, cytoplasmic isoform 3
NM_001317965.2	NP_001304894.1	leucine--tRNA ligase, cytoplasmic isoform 4
NM_016460.4	NP_057544.2	leucine--tRNA ligase, cytoplasmic isoform 2
NM_020117.11	NP_064502.9	leucine--tRNA ligase, cytoplasmic isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IMP IMP: 通过突变表型推断	22424946	GOA
enables aminoacyl-tRNA editing activity	IDA IDA: 通过直接分析推断	25051973	GOA
enables glutamine-tRNA ligase activity	IDA IDA: 通过直接分析推断	26869582	GOA
enables leucine-tRNA ligase activity	IDA IDA: 通过直接分析推断	25051973	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16055448	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to L-leucine	IMP IMP: 通过突变表型推断	22424946	GOA
involved in cellular response to amino acid starvation	IMP IMP: 通过突变表型推断	22424946	GOA
involved in cellular response to amino acid stimulus	IMP IMP: 通过突变表型推断	22424946	GOA
involved in cellular response to leucine starvation	IMP IMP: 通过突变表型推断	22424946	GOA
involved in glutaminyl-tRNA aminoacylation	IDA IDA: 通过直接分析推断	26869582	GOA
involved in leucyl-tRNA aminoacylation	IDA IDA: 通过直接分析推断	25051973	GOA
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	22424946	GOA
involved in positive regulation of TOR signaling	IMP IMP: 通过突变表型推断	22424946	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: 通过突变表型推断	22424946	GOA
involved in regulation of cell size	IMP IMP: 通过突变表型推断	22424946	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: 通过直接分析推断	19131329	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22424946	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19289464	GOA
located in endomembrane system	IDA IDA: 通过直接分析推断	22424946	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	22424946	GOA
located in lysosome	IMP IMP: 通过突变表型推断	22424946	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LARS1 蛋白结构

tRNA-synt_1

Anticodon_1

0
200
400
600
800
1000
1176 a.a.

蛋白主名

其他名称

leucine--tRNA ligase, cytoplasmic

cytoplasmic leucyl-tRNA synthetase

LARS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LARS1	Q9P2J5	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	22424946
种属内	LARS1	Q9P2J5	RARS1	Homo sapiens	P54136	Anti Tag CoIP	33961781
种属内	LARS1	Q9P2J5	RARS1	Homo sapiens	P54136	Anti Tag CoIP	16055448
种属内	LARS1	Q9P2J5	RRAGD	Homo sapiens	Q9NQL2	Pull Down	22424946

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Infantile Liver Failure Syndrome 1

ILFS1	Acute Infantile Liver Failure-Multisystemic Involvement Syndrome
Liver Failure Syndrome, Infantile, Type 1	Liver Failure

Infantile Liver Failure Syndrome

Infantile Liver Failure

Liver Failure, Infantile, Transient

Acute Infantile Liver Failure Due To Synthesis Defect Of Mtdna-Encoded Proteins	Transient Infantile Liver Failure
LFIT	Acute Infantile Liver Failure
Acute Infantile Liver Failure Due To Synthesis Defect Of Mitochondrial Dna-Encoded Proteins	Liver Failure, Transient Infantile
Acute Infantile Liver Failure Due To Mtdna-Encoded Proteins Synthesis Defect	Liver Failure, Acute Infantile
Failure, Liver, Transient, Infantile

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Cecum Lymphoma

Cecal Lymphoma

Tremor, Hereditary Essential, 2

ETM2	Essential Tremor 2
Essential Tremor, Hereditary, 2	Hereditary Essential Tremor 2
Tremor Hereditary Essential, 2

Fetishism

Fetishism, Psychiatric

Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant

Meckel'S Diverticulitis

Meckel Diverticulitis

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome	MERRF
Fukuhara Syndrome	Myoclonic Epilepsy Associated With Ragged Red Fibers
Myoencephalopathy Ragged-Red Fiber Disease	Myoclonic Epilepsy - Ragged Red Fibers
Myoclonus Epilepsy And Ragged Red Fibers	Myoclonus With Epilepsy And With Ragged Red Fibers
Myoclonic Epilepsy With Ragged Red Fibers	Myoclonic Epilepsy With Ragged-Red Fibers
Fukuhara Disease	Myoclonus Epilepsy Associated With Ragged-Red Fibres
Myoclonus With Epilepsy With Ragged Red Fibers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07532	LARS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LARS1	VGNC	VGNC:84403
Rattus norvegicus	LARS1	RGD	RGD:1304962
Mus musculus	LARS1	MGD	MGI:1913808
Bos taurus	LARS1	VGNC	VGNC:30795
Canis familiaris	LARS1	VGNC	VGNC:42592
Felis catus	LARS1	VGNC	VGNC:68020

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LARS1 - leucyl-tRNA synthetase 1 Gene

关于 LARS1

功能概要

LARS1 基因产物(4)

LARS1 蛋白结构

LARS1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LARS1 - leucyl-tRNA synthetase 1 Gene

关于 LARS1

功能概要

LARS1 基因产物(4)

LARS1 蛋白结构

LARS1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z