2. Gene
  3. ACKR4 - atypical chemokine receptor 4 Gene

ACKR4 - atypical chemokine receptor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：非典型趋化因子受体 4

种属: Homo sapiens

同用名: PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11

基因 ID: 51554 | 基因类型: protein coding

关于 ACKR4

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:132,597,270-132,602,644 (from NCBI)

This gene has 2 transcripts (splice variants), 256 orthologues and 23 paralogues. Broad expression in duodenum (RPKM 8.4), small intestine (RPKM 7.1) and 16 other tissues.

功能概要

该基因编码的蛋白质是 G 蛋白偶联受体家族的一员，是 CC 型趋化因子的受体。该受体已被证明可结合树突状细胞和 T 细胞激活的趋化因子，包括 CCL19/ELC、CCL21/SLC 和 CCL25/TECK。在 6 号染色体上发现了该基因的假基因。已经描述了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

ACKR4 基因产物(2)

mRNA Protein Name
NM_016557.4 NP_057641.1 atypical chemokine receptor 4
NM_178445.2 NP_848540.1 atypical chemokine receptor 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine receptor activity IDA
IDA: 通过直接分析推断
23341447 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23341447 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACKR4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 303)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

atypical chemokine receptor 4

C-C CKR-11

关联疾病

疾病名称 别名
Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00165 ACKR4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ACKR4 VGNC VGNC:69418
Mus musculus ACKR4 MGD MGI:2181676
Bos taurus ACKR4 VGNC VGNC:25542
Rattus norvegicus ACKR4 RGD RGD:1596453
Felis catus ACKR4 VGNC VGNC:59512
Canis familiaris ACKR4 VGNC VGNC:37510
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