2. Gene
  3. RAB6B - RAB6B, member RAS oncogene family Gene

RAB6B - RAB6B, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB6B，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 51560 | 基因类型: protein coding

关于 RAB6B

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,824,235-133,895,882 (from NCBI)

This gene has 7 transcripts (splice variants), 249 orthologues and 68 paralogues. Biased expression in brain (RPKM 76.4), heart (RPKM 6.6) and 1 other tissue.

功能概要

启用肌球蛋白 V 结合活动。预计参与高尔基体小泡转运；细胞内蛋白质转运；和逆行运输，内体到高尔基体。位于高尔基体。 [由基因组资源联盟提供，2022 年 4 月]

Enables Myosin V binding activity. Predicted to be involved in Golgi vesicle transport; intracellular protein transport; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

RAB6B 基因产物(2)

mRNA Protein Name
NM_001363953.1 NP_001350882.1 ras-related protein Rab-6B isoform 2
NM_016577.4 NP_057661.3 ras-related protein Rab-6B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables myosin V binding IPI
IPI: 通过物理相互作用推断
24006491 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23737971 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
26209634 GOA
involved in protein localization to Golgi membrane IDA
IDA: 通过直接分析推断
25492866 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
25492866 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB6B 蛋白结构

Ras

Ras: Ras family (15 - 173)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

ras-related protein Rab-6B

small GTP-binding protein

RAB6B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB6B Q9NRW1 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
种属内
RAB6B Q9NRW1 RAP1GDS1 Homo sapiens P52306-5
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 RAP1GDS1 Homo sapiens P52306-5
Y2H Array
32296183
种属内
RAB6B Q9NRW1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
RAB6B Q9NRW1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 SH2B2 Homo sapiens O14492-2
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 SH2B2 Homo sapiens O14492-2
Y2H Array
32296183
种属内
RAB6B Q9NRW1 COG6 Homo sapiens Q9Y2V7
Validated Y2H
27107012
种属内
RAB6B Q9NRW1 COG6 Homo sapiens Q9Y2V7
BFG-2H
27107012
种属内
RAB6B Q9NRW1 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
种属内
RAB6B Q9NRW1 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
种属内
RAB6B Q9NRW1 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 PMM1 Homo sapiens Q92871
Y2H Prey Pooling
32296183
种属内
RAB6B Q9NRW1 PMM1 Homo sapiens Q92871
Y2H Array
32296183
种属内
RAB6B Q9NRW1 APBA1 Homo sapiens Q02410-2
Y2H
23737971
种属内
RAB6B Q9NRW1 APBA1 Homo sapiens Q02410-2
Pull Down
23737971
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cohen Syndrome

Pepper Syndrome

COH1

Hypotonia, Obesity, And Prominent Incisors

Coh

Chs1, Formerly

Norio Syndrome

Obesity-Hypotonia Syndrome

Prominent Incisors-Obesity-Hypotonia Syndrome

Chs1

Hypotonia-Obesity-Prominent Incisors

Stage 4s Neuroblastoma
Charcot-Marie-Tooth Disease, Recessive Intermediate A

Charcot-Marie-Tooth Disease Recessive Intermediate A

CMTRIA

Ri-Cmta

Charcot-Marie-Tooth Disease, Recessive Intermediate, A

Autosomal Recessive Intermediate Charcot-Marie-Tooth Disease Type A

Charcot-Marie-Tooth Neuropathy Recessive Intermediate A

Charcot-Marie-Tooth Neuropathy, Recessive Intermediate A

Ri-Cmt Type A

Charcot-Marie-Tooth Disease, Recessive, Intermediate Type, A
Corneal Dystrophy, Fleck

Fleck Corneal Dystrophy

Fcd

CFD

Corneal Fleck Dystrophy

Francois-Neetens Speckled Corneal Dystrophy

Corneal Dystrophy, Francois-Neetens Speckled Or Flecked

Corneal Dystrophy Francois-Neetens Speckled Or Flecked

Dystrophy, Corneal, Fleck
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11575 RAB6B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RAB6B VGNC VGNC:59057
Bos taurus RAB6B VGNC VGNC:50013
Rattus norvegicus RAB6B RGD RGD:1309958
Mus musculus RAB6B MGD MGI:107283
Macaca mulatta RAB6B VGNC VGNC:81547
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