TRIM33 - tripartite motif containing 33 Gene

中文名称：含三方基序 33

种属: Homo sapiens

同用名: ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

基因 ID: 51592 | 基因类型: protein coding

关于 TRIM33

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,392,790-114,511,203 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 80 paralogues and is associated with 80 phenotypes. Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质被认为是转录辅阻遏物。然而，与这种蛋白质相互作用的分子尚未确定。该蛋白质是三联基序家族的成员。该基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。已经描述了该基因的三种可变剪接转录物变体，但是，尚未确定一种变体的全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

TRIM33 基因产物(2)

mRNA	Protein	Name
NM_015906.4	NP_056990.3	E3 ubiquitin-protein ligase TRIM33 isoform alpha
NM_033020.3	NP_148980.2	E3 ubiquitin-protein ligase TRIM33 isoform beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables R-SMAD binding	IPI IPI: 通过物理相互作用推断	19135894	GOA
enables co-SMAD binding	IPI IPI: 通过物理相互作用推断	19135894	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19135894	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of BMP signaling pathway	IDA IDA: 通过直接分析推断	19135894	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	19135894	GOA
involved in regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	19135894	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19135894	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM33 蛋白结构

zf-RING_2

zf-B_box

PHD

Bromodomain

0
200
400
600
800
1000
1127 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRIM33

RET-fused gene 7 protein

TRIM33 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Tag CoIP	20603019
种属内	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Bait CoIP	19135894
种属内	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Tag CoIP	19135894
种属内	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Tag CoIP	26496610
种属内	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Bait CoIP	21531907
种属内	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Tag CoIP	35271311
种属内	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	20603019
种属内	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	21597466
种属内	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	19135894
种属内	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	19135894

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Orbital Plasma Cell Granuloma

Orbital Myositis	Orbital Pseudotumor
Pseudotumor Of Orbit	Plasma Cell Granuloma, Orbital

Renal Pelvis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Kidney Pelvis

Squamous Cell Carcinoma Of Renal Pelvis

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Granulomatous Myositis

Chronic Orbital Inflammation

Chronic Inflammation Of Orbit

Muscle Tissue Disease

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Exanthem

Exanthema	Rash
Rashes

Muscular Disease

Myopathy

Muscular Diseases

Myopathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15038	TRIM33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TRIM33	VGNC	VGNC:107684
Mus musculus	TRIM33	MGD	MGI:2137357
Macaca mulatta	TRIM33	VGNC	VGNC:79028
Bos taurus	TRIM33	VGNC	VGNC:36329
Rattus norvegicus	TRIM33	RGD	RGD:1307339
Canis familiaris	TRIM33	VGNC	VGNC:47815

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRIM33 - tripartite motif containing 33 Gene

关于 TRIM33

功能概要

TRIM33 基因产物(2)

TRIM33 蛋白结构

TRIM33 蛋白互作信息

关联疾病

直系同源

热门区域

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TRIM33 - tripartite motif containing 33 Gene

关于 TRIM33

功能概要

TRIM33 基因产物(2)

TRIM33 蛋白结构

TRIM33 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z