1. Gene
  2. NOP58 - NOP58 ribonucleoprotein Gene

NOP58 - NOP58 ribonucleoprotein Gene

中文名称:NOP58 核糖核蛋白

种属: Homo sapiens

同用名: NOP5; HSPC120; NOP5/NOP58

基因 ID: 51602 | 基因类型: protein coding

关于 NOP58

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,265,763-202,303,661 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是 box C/D 小核仁核糖核蛋白的核心成分。一些盒式 C/D 小核仁 RNA (snoRNA) ,例如 U3、U8 和 U14,它们的合成依赖于编码的蛋白质。这种蛋白质是 SUMO 化的,这是与 snoRNA 高亲和力结合所必需的。[RefSeq 提供,2015 年 11 月]

The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

NOP58 基因产物(1)

mRNA Protein Name
NM_015934.5 NP_057018.1 nucleolar protein 58
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
17636026 GOA
enables TFIID-class transcription factor complex binding IPI
IPI: 通过物理相互作用推断
17636026 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17636026 GOA
enables snoRNA binding IDA
IDA: 通过直接分析推断
17636026 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
involved in snoRNA localization IMP
IMP: 通过突变表型推断
17636026 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
16687569 GOA
part of box C/D methylation guide snoRNP complex IDA
IDA: 通过直接分析推断
33367824 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
16687569 GOA
part of pre-snoRNP complex IDA
IDA: 通过直接分析推断
17636026 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
part of sno(s)RNA-containing ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17636026 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NOP58 蛋白结构

NOP5NT

NOP5NT: NOP5NT (NUC127) domain (1 - 66)

(161 - 213)

Nop

Nop: snoRNA binding domain, fibrillarin (253 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
蛋白主名 其他名称

nucleolar protein 58

NOP58 ribonucleoprotein homolog

NOP58 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NOP58 Q9Y2X3 NUFIP1 Homo sapiens Q9UHK0
Anti Bait CoIP
17636026
种属内
NOP58 Q9Y2X3 NUFIP1 Homo sapiens Q9UHK0
Anti Tag CoIP
35271311
种属内
NOP58 Q9Y2X3 NOPCHAP1 Homo sapiens Q8N5I9
Anti Tag CoIP
35271311
种属内
NOP58 Q9Y2X3 NOPCHAP1 Homo sapiens Q8N5I9
Anti Tag CoIP
33961781
种属内
NOP58 Q9Y2X3 SNU13 Homo sapiens P55769
Crosslink
30021884
种属内
NOP58 Q9Y2X3 SNU13 Homo sapiens P55769
Anti Tag CoIP
35271311
种属内
NOP58 Q9Y2X3 TGS1 Homo sapiens Q96RS0
Pull Down
21522132
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NOP58 RGD RGD:620484
Canis familiaris NOP58 VGNC VGNC:43892
Bos taurus NOP58 VGNC VGNC:32170
Felis catus NOP58 VGNC VGNC:63859
Macaca mulatta NOP58 VGNC VGNC:75284
Mus musculus NOP58 MGD MGI:1933184