2. Gene
  3. ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外核苷酸焦磷酸酶/磷酸二酯酶 3

种属: Homo sapiens

同用名: B10; NPP3; PDNP3; CD203c; PD-IBETA

基因 ID: 5169 | 基因类型: protein coding

关于 ENPP3

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,637,302-131,747,410 (from NCBI)

This gene has 7 transcripts (splice variants), 146 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 19.6), duodenum (RPKM 6.7) and 6 other tissues.

功能概要

该基因编码的蛋白质属于一系列参与胞外核苷酸水解的胞外酶。这些胞外酶具有 ATP 酶和 ATP 焦磷酸酶活性，是 II 型跨膜蛋白。已在未成熟神经胶质细胞亚群和消化道中发现相关大鼠 mRNA 的表达。已在胰腺、小肠、结肠和肝脏中检测到相应的大鼠蛋白。人类 mRNA 在神经胶质瘤细胞、前列腺和子宫中表达。已在子宫、嗜碱性粒细胞和肥大细胞中检测到人类蛋白质的表达。已发现该基因的两种转录变体，一种是蛋白质编码，另一种是非蛋白质编码。[RefSeq 提供，2015 年 10 月]

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

ENPP3 基因产物(1)

mRNA Protein Name
NM_005021.5 NP_005012.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bis(5'-adenosyl)-pentaphosphatase activity IDA
IDA: 通过直接分析推断
12846830 GOA
enables bis(5'-adenosyl)-triphosphatase activity IDA
IDA: 通过直接分析推断
12846830 GOA
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IDA
IDA: 通过直接分析推断
12846830 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
29717535 GOA
enables nucleoside triphosphate diphosphatase activity IDA
IDA: 通过直接分析推断
10513816 GOA
enables phosphodiesterase I activity IMP
IMP: 通过突变表型推断
11342463 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
29717535 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP metabolic process IDA
IDA: 通过直接分析推断
29717535 GOA
NOT involved in inorganic diphosphate transport IDA
IDA: 通过直接分析推断
10513816 GOA
involved in nucleoside triphosphate catabolic process IDA
IDA: 通过直接分析推断
10513816 GOA
involved in phosphate-containing compound metabolic process IDA
IDA: 通过直接分析推断
10513816 GOA
involved in pyrimidine nucleotide metabolic process IMP
IMP: 通过突变表型推断
11342463 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
11342463 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10513816 GOA
is active in plasma membrane IDA
IDA: 通过直接分析推断
12846830 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENPP3 蛋白结构

Somatomedin_B

Somatomedin_B: Somatomedin B domain (51 - 93)

Somatomedin_B

Somatomedin_B: Somatomedin B domain (96 - 137)

Phosphodiest

Phosphodiest: Type I phosphodiesterase / nucleotide pyrophosphatase (161 - 486)

Endonuclease_NS

Endonuclease_NS: DNA/RNA non-specific endonuclease (704 - 852)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 875 a.a.
蛋白主名 其他名称

ectonucleotide pyrophosphatase/phosphodiesterase family member 3

dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)

重组 ENPP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77924 ENPP-3 Protein, Human (828a.a, HEK293, His-Avi) O14638 (L48-I875) ≥95%
HY-P77925 ENPP-3 Protein, Human (Biotinylated, 828a.a, HEK293, His-Avi) O14638 (L48-I875) ≥95%
HY-P77926 ENPP-3 Protein, Human (110a.a, HEK293, His-Avi) O14638 (L48-D157) ≥95%
HY-P77927 ENPP-3 Protein, Human (Biotinylated, 110a.a, HEK293, His-Avi) O14638 (L48-D157) ≥95%
HY-P77928 ENPP-3 Protein, Human (318a.a, HEK293, His) O14638 (K558-I875) ≥95%
HY-P700410 ENPP-3 Protein, Human (828a.a, HEK293, His) O14638 (L48-I875) ≥95%

关联疾病

疾病名称 别名
Amoxicillin Allergy
Beta-Lactam Allergy
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Apricot Allergy

Prunus Armeniaca Fruit Allergy
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Cephalosporin Allergy
Crab Allergy

Green Mud Crab Allergy

Scylla Paramamosain Allergy
Chlorhexidine Allergy
Acute Basophilic Leukemia
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Diclofenac Allergy

Voltaren Allergy
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10

Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures

Optic Atrophy 10

Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Drug Allergy

Allergy Drug

Drug Allergies
Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy
Physical Urticaria

Symptomatic Dermographism
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis
Peach Allergy

Prunus Persica Fruit Allergy
Nut Allergy

Nut Allergic Reaction

Nut Hypersensitivity

Allergy To Nuts

Allergy Nut
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Carbapenem Allergy
Cholinergic Urticaria
Pollen Allergy

Hay Fever
Fruit Allergy

Allergy To Fruit
Legume Allergy

Fabaceae Allergy
Egg Allergy

Allergy To Eggs

Allergies Egg

Egg Hypersensitivity
Latex Allergy
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus
Peanut Allergy

Allergy To Peanuts

Peanut Allergic Reaction

Allergies Peanut

Peanut Hypersensitivity
Wheat Allergy

Wheat Allergic Reaction

Wheat Hypersensitivity

Allergy To Wheat

Allergy Wheat
Penicillin Allergy

Allergy To Penicillin
Arterial Calcification Of Infancy

Idiopathic Infantile Arterial Calcification

Generalized Arterial Calcification Of Infancy

Iiac

Occlusive Infantile Arteriopathy

Infantile Arteriosclerosis

Gaci

Idiopathic Obliterative Arteriopathy

Generalized Arterial Calcification In Infancy

Arteriopathia Calcificans Infantum

Diffuse Arterial Calcifying Elastopathy Of Infancy

Infantile Calcifying Arteriopathy

Medial Coronary Sclerosis Of Infancy

Coronary Sclerosis, Medial, Of Infancy

Calcification, Arterial, Generalized, Infancy
Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma

Skin Mastocytoma

Solitary Mastocytoma

Solitary Mastocytoma Of Skin

Mastocytoma, Skin
Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity
Aggressive Systemic Mastocytosis

Asm

Lymphadenopathic Mastocytosis With Eosinophilia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147998 Enpp-1-IN-13 Inhibitor / 否
HY-RS04389 ENPP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-169804 ENPP3 Inhibitor 1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ENPP3 VGNC VGNC:28506
Mus musculus ENPP3 MGD MGI:2143702
Canis familiaris ENPP3 VGNC VGNC:40376
Macaca mulatta ENPP3 VGNC VGNC:72224
Felis catus ENPP3 VGNC VGNC:61874
Rattus norvegicus ENPP3 RGD RGD:708511
Macaca fascicularis ENPP3 NCBI NCBI:102132755
Others ENPP3 NCBI
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