2. Gene
  3. RAPGEF6 - Rap guanine nucleotide exchange factor 6 Gene

RAPGEF6 - Rap guanine nucleotide exchange factor 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Rap 鸟嘌呤核苷酸交换因子 6

种属: Homo sapiens

同用名: RAGEF2; PDZGEF2; KIA001LB; PDZ-GEF2; RA-GEF-2

基因 ID: 51735 | 基因类型: protein coding

关于 RAPGEF6

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:131,423,921-131,635,229 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 9.8), appendix (RPKM 6.5) and 24 other tissues.

功能概要

启用多种功能，包括 GTP 依赖性蛋白结合活性；胍基核苷酸交换因子活性；和磷脂酸结合活性。参与微绒毛组装； GTP 酶活性的正调节；和蛋白质定位到质膜。位于几种细胞成分中，包括顶端质膜；中心体；和内吞囊泡。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

RAPGEF6 基因产物(6)

mRNA Protein Name
NM_001164386.2 NP_001157858.1 rap guanine nucleotide exchange factor 6 isoform 1
NM_001164387.2 NP_001157859.1 rap guanine nucleotide exchange factor 6 isoform 3
NM_001164388.2 NP_001157860.1 rap guanine nucleotide exchange factor 6 isoform 4
NM_001164389.2 NP_001157861.1 rap guanine nucleotide exchange factor 6 isoform 5
NM_001164390.2 NP_001157862.1 rap guanine nucleotide exchange factor 6 isoform 6
NM_016340.6 NP_057424.3 rap guanine nucleotide exchange factor 6 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP-dependent protein binding IDA
IDA: 通过直接分析推断
11524421 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
11524421 GOA
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
22797597 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12095257 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
11524421 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
23885123 GOA
involved in microvillus assembly IGI
IGI: 通过遗传相互作用推断
22797597 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
22797597 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
22797597 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
22797597 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22797597 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
22797597 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11524421 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAPGEF6 蛋白结构

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (303 - 381)

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (416 - 502)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (530 - 608)

RA

RA: Ras association (RalGDS/AF-6) domain (751 - 833)

RasGEF

RasGEF: RasGEF domain (857 - 1042)

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  • 1601 a.a.
蛋白主名 其他名称

rap guanine nucleotide exchange factor 6

PDZ domain containing guanine nucleotide exchange factor (GEF) 2

RAPGEF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAPGEF6 Q8TEU7 PTPN13 Homo sapiens Q12923
Biophysical
17240990
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11665 RAPGEF6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RAPGEF6 RGD RGD:1307645
Mus musculus RAPGEF6 MGD MGI:2384761
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