PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

中文名称：6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 1

种属: Homo sapiens

同用名: F6PK; HL2K; PFRX

基因 ID: 5207 | 基因类型: protein coding

关于 PFKFB1

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:54,932,961-54,998,789 (from NCBI)

This gene has 4 transcripts (splice variants), 261 orthologues and 3 paralogues. Biased expression in fat (RPKM 14.1) and liver (RPKM 5.1).

功能概要

该基因编码双功能 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 酶家族的成员。该酶形成同型二聚体，使用独立的催化结构域催化 2,6-二磷酸果糖的合成和降解。 2,6-二磷酸果糖是糖酵解途径的激活剂和糖异生途径的抑制剂。因此，通过这种酶的活性调节果糖 2,6-二磷酸水平被认为可以调节葡萄糖稳态。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase Enzymes. The Enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this Enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

PFKFB1 基因产物(3)

mRNA	Protein	Name
NM_001271804.2	NP_001258733.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271805.2	NP_001258734.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_002625.4	NP_002616.2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

PFKFB1 蛋白结构

6PF2K

His_Phos_1

0
100
200
300
400
471 a.a.

蛋白主名

其他名称

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

6PF-2-K/Fru-2,6-P2ASE liver isozyme

PFKFB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PFKFB1	P16118	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	VWC2	Homo sapiens	Q2TAL6	Validated Y2H	32296183
种属内	PFKFB1	P16118	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
种属内	PFKFB1	P16118	PDE4A	Homo sapiens	P27815-4	Validated Y2H	32296183
种属内	PFKFB1	P16118	PDE4A	Homo sapiens	P27815-4	Y2H Array	32296183
种属内	PFKFB1	P16118	PDE4A	Homo sapiens	P27815-4	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	ZNF474	Homo sapiens	Q6S9Z5	Validated Y2H	32296183
种属内	PFKFB1	P16118	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
种属内	PFKFB1	P16118	ZNF688	Homo sapiens	P0C7X2	Y2H Array	32296183
种属内	PFKFB1	P16118	ZNF688	Homo sapiens	P0C7X2	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
种属内	PFKFB1	P16118	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
种属内	PFKFB1	P16118	PFKFB4	Homo sapiens	Q16877	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	PFKFB1	P16118	PFKFB4	Homo sapiens	Q16877	Validated Y2H	32296183
种属内	PFKFB1	P16118	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
种属内	PFKFB1	P16118	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	PFKFB4	Homo sapiens	Q16877	Y2H Array	32296183
种属内	PFKFB1	P16118	PFKFB1	Homo sapiens	P16118	Validated Y2H	32296183
种属内	PFKFB1	P16118	PFKFB1	Homo sapiens	P16118	Y2H Array	25416956
种属内	PFKFB1	P16118	GCK	Homo sapiens	P35557	ELISA	11522786
种属内	PFKFB1	P16118	PFKFB1	Homo sapiens	P16118	X-Ray Diffraction	12379646
种属内	PFKFB1	P16118	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
种属内	PFKFB1	P16118	PFKFB1	Homo sapiens	P16118	Y2H Array	32296183
种属内	PFKFB1	P16118	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	PFKFB1	Homo sapiens	P16118	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	PFKFB1	P16118	ZNF276	Homo sapiens	Q8N554	Y2H Array	32296183
种属内	PFKFB1	P16118	ZNF276	Homo sapiens	Q8N554	Validated Y2H	32296183
种属内	PFKFB1	P16118	ZNF276	Homo sapiens	Q8N554	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	PFKFB3	Homo sapiens	Q16875	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	PFKFB3	Homo sapiens	Q16875	Validated Y2H	32296183
种属内	PFKFB1	P16118	PFKFB3	Homo sapiens	Q16875	Y2H Array	32296183
种属内	PFKFB1	P16118	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
种属内	PFKFB1	P16118	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
种属内	PFKFB1	P16118	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PFKFB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71118	PFKFB1 Protein, Human (HEK293, His)	P16118 (S2-Y471)	≥95%

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101972	AZ-PFKFB3-67	Inhibitor	97.20%	否
HY-101971	AZ PFKFB3 26	Inhibitor	99.23%	否
HY-101972A	AZ-PFKFB3-67 quarterhydrate	Inhibitor	≥99.0%	否
HY-RS10361	PFKFB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PFKFB1	MGD	MGI:107816
Rattus norvegicus	PFKFB1	RGD	RGD:3307
Felis catus	PFKFB1	VGNC	VGNC:68803
Bos taurus	PFKFB1	VGNC	VGNC:32769
Canis familiaris	PFKFB1	VGNC	VGNC:44442
Macaca mulatta	PFKFB1	VGNC	VGNC:75957
Others	PFKFB1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

关于 PFKFB1

功能概要

PFKFB1 基因产物(3)

PFKFB1 蛋白结构

PFKFB1 蛋白互作信息

重组 PFKFB1 蛋白

关联疾病

直系同源

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PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

关于 PFKFB1

功能概要

PFKFB1 基因产物(3)

PFKFB1 蛋白结构

PFKFB1 蛋白互作信息

重组 PFKFB1 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

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T

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