SERPINB13 - serpin family B member 13 Gene

中文名称：serpin 家族 B 成员 13

种属: Homo sapiens

同用名: HUR7; PI13; headpin; HSHUR7SEQ

基因 ID: 5275 | 基因类型: protein coding

关于 SERPINB13

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,587,343-63,599,192 (from NCBI)

This gene has 6 transcripts (splice variants), 82 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 94.0).

功能概要

由该基因编码的蛋白质是丝氨酸蛋白酶抑制剂 serpin 家族的成员。编码的蛋白质抑制组织蛋白酶 K 的活性，并且其自身在转录上受到 RUNX1 的抑制。该基因在许多类型的癌症中被下调。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is a member of the serpin family of serine Protease Inhibitors. The encoded protein inhibits the activity of Cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of Cancer. [provided by RefSeq, Jan 2017]

SERPINB13 基因产物(6)

mRNA	Protein	Name
NM_001307923.2	NP_001294852.1	serpin B13 isoform 1
NM_001348267.2	NP_001335196.1	serpin B13 isoform 3
NM_001348268.2	NP_001335197.1	serpin B13 isoform 3
NM_001348269.2	NP_001335198.1	serpin B13 isoform 4
NM_001348270.2	NP_001335199.1	serpin B13 isoform 4
NM_012397.4	NP_036529.1	serpin B13 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	12504904	GOA
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	12809493	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	12504904	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
NOT enables serine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	12504904	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of endopeptidase activity	IDA IDA: 通过直接分析推断	12504904	GOA
involved in negative regulation of keratinocyte apoptotic process	IMP IMP: 通过突变表型推断	12809493	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12809493	GOA
NOT located in nucleolus	IDA IDA: 通过直接分析推断	12809493	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	12809493	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINB13 蛋白结构

Serpin

0
100
200
300
391 a.a.

蛋白主名

其他名称

serpin B13

HURPIN

SERPINB13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SERPINB13	Q9UIV8	DLG2	Homo sapiens	Q15700	Y2H Prey Pooling	32296183
种属内	SERPINB13	Q9UIV8	DLG2	Homo sapiens	Q15700	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Psoriasis

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12709	SERPINB13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SERPINB13	VGNC	VGNC:34472
Macaca mulatta	SERPINB13	VGNC	VGNC:104246
Mus musculus	SERPINB13	MGD	MGI:3042250
Canis familiaris	SERPINB13	VGNC	VGNC:46029
Rattus norvegicus	SERPINB13	RGD	RGD:1304661

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SERPINB13 - serpin family B member 13 Gene

关于 SERPINB13

功能概要

SERPINB13 基因产物(6)

SERPINB13 蛋白结构

SERPINB13 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SERPINB13 - serpin family B member 13 Gene

关于 SERPINB13

功能概要

SERPINB13 基因产物(6)

SERPINB13 蛋白结构

SERPINB13 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z