2. Gene
  3. PI4KB - phosphatidylinositol 4-kinase beta Gene

PI4KB - phosphatidylinositol 4-kinase beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 4-激酶 β

种属: Homo sapiens

同用名: NPIK; PI4K92; PIK4CB; PI4KIII; PI4KBETA; PI4K-BETA; PI4KIIIBETA

基因 ID: 5298 | 基因类型: protein coding

关于 PI4KB

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,291,797-151,327,715 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.6) and 25 other tissues.

功能概要

启用 1-磷脂酰肌醇 4-激酶活性和 14-3-3 蛋白结合活性。预计参与磷脂酰肌醇磷酸盐生物合成过程和磷脂酰肌醇介导的信号传导。位于高尔基体膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

PI4KB 基因产物(15)

mRNA Protein Name
XM_011509634.2 XP_011507936.1 phosphatidylinositol 4-kinase beta isoform X1
NM_001198774.2 NP_001185703.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369628.1 NP_001356557.1 phosphatidylinositol 4-kinase beta isoform 8
NM_002651.4 NP_002642.1 phosphatidylinositol 4-kinase beta isoform 1
NM_001198775.3 NP_001185704.1 phosphatidylinositol 4-kinase beta isoform 3
XM_047422590.1 XP_047278546.1 phosphatidylinositol 4-kinase beta isoform X3
NM_001369629.2 NP_001356558.1 phosphatidylinositol 4-kinase beta isoform 5
XM_017001488.2 XP_016856977.1 phosphatidylinositol 4-kinase beta isoform X2
NM_001369623.2 NP_001356552.1 phosphatidylinositol 4-kinase beta isoform 5
NM_001330721.2 NP_001317650.1 phosphatidylinositol 4-kinase beta isoform 5
NM_001369625.1 NP_001356554.1 phosphatidylinositol 4-kinase beta isoform 6
NM_001198773.3 NP_001185702.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369624.1 NP_001356553.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369626.1 NP_001356555.1 phosphatidylinositol 4-kinase beta isoform 7
XM_017001486.2 XP_016856975.1 phosphatidylinositol 4-kinase beta isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: 通过直接分析推断
11277933 GOA
enables 14-3-3 protein binding IDA
IDA: 通过直接分析推断
23572552 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16912074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inner ear development IMP
IMP: 通过突变表型推断
33358777 GOA
acts upstream of or within lysosome organization IDA
IDA: 通过直接分析推断
25365221 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
25365221 GOA
located in Golgi membrane IDA
IDA: 通过直接分析推断
27009356 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PI4KB 蛋白结构

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (561 - 754)

  • 0
  • 200
  • 400
  • 600
  • 816 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-kinase beta

PtdIns 4-kinase beta

phosphatidylinositol 4-kinase, catalytic, beta

phosphatidylinositol 4-kinase, wortmannin-sensitive

type III phosphatidylinositol 4-kinase beta

PI4KB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PI4KB Q9UBF8 ACBD3 Homo sapiens Q9H3P7
Y2H
22124328
种属内
PI4KB Q9UBF8 ACBD3 Homo sapiens Q9H3P7
Anti Tag CoIP
22124328
种属内
PI4KB Q9UBF8 YWHAQ Homo sapiens P27348
Pull Down
16912074
种属内
PI4KB Q9UBF8 YWHAQ Homo sapiens P27348
CoIP
15324660
种属间
PI4KB Q9UBF8 P03300-PRO_0000424692 Poliovirus type 1 P03300-PRO_0000424692
Pull Down
23572552
种属间
PI4KB Q9UBF8 NS Influenza A virus P03495
Pull Down
24008843
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Nonparalytic Poliomyelitis

Acute Nonparalytic Poliomyelitis

Non-Paralytic Aseptic Meningitis
Mouth Disease

Mouth Diseases

Mouth Disorders
Lowe Oculocerebrorenal Syndrome

Lowe Syndrome

Oculocerebrorenal Syndrome

OCRL

Oculocerebrorenal Syndrome Of Lowe

Ocrl1

Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency

Lowe Disease

Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency

Cerebrooculorenal Syndrome

Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency

Lowe Oculo-Cerebro-Renal Dystrophy

Lowe Oculo-Cerebro-Renal Syndrome

Lowe Oculocerebrorenal Dystrophy

Low

Chromosome 11p Deletion Syndrome

Oculocerebrorenal Dystrophy

Cerebro-Oculorenal Dystrophy

Ocrl1 - [Oculocerebrorenal Syndrome]

Lowe-Terrey-Maclachlan Syndrome

Renal-Oculocerebrodystrophy
Poliomyelitis

Infantile Paralysis

Polio
Acute Flaccid Myelitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108313 T-00127_HEV1 Inhibitor 99.97% 否
HY-100603 GSK-F1 Inhibitor 95.00% 否
HY-22055B AN-12-H5 intermediate-1 99.72% 否
HY-120900 AN-12-H5 Inhibitor 98.03% 否
HY-W047496 AN-12-H5 intermediate-2 ≥97.0% 否
HY-RS10469 PI4KB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10470 Pi4kb Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10471 Pi4kb Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W451820 AN-12-H5 intermediate-3 95.82% 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PI4KB VGNC VGNC:76000
Canis familiaris PI4KB VGNC VGNC:44517
Bos taurus PI4KB VGNC VGNC:32854
Felis catus PI4KB VGNC VGNC:68860
Rattus norvegicus PI4KB RGD RGD:621214
Mus musculus PI4KB MGD MGI:1334433
Others PI4KB NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z