UBASH3A - ubiquitin associated and SH3 domain containing A Gene

中文名称：含泛素相关和 SH3 结构域 A

种属: Homo sapiens

同用名: TULA; CLIP4; STS-2; TULA-1

关于 UBASH3A

功能概要

该基因编码属于 T 细胞泛素配体 (TULA) 家族的两个家族成员之一。两个家族成员都可以负向调节 T 细胞信号。该家族成员可以促进 T 细胞中生长因子戒断诱导的细胞凋亡，这可能是通过它与 AIF (一种细胞凋亡诱导因子) 的相互作用而发生的。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2011 年 8 月]

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced Apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]