2. Gene
  3. UBASH3A - ubiquitin associated and SH3 domain containing A Gene

UBASH3A - ubiquitin associated and SH3 domain containing A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含泛素相关和 SH3 结构域 A

种属: Homo sapiens

同用名: TULA; CLIP4; STS-2; TULA-1

基因 ID: 53347 | 基因类型: protein coding

关于 UBASH3A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,403,902-42,447,684 (from NCBI)

This gene has 9 transcripts (splice variants), 132 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 3.3), appendix (RPKM 1.9) and 12 other tissues.

功能概要

该基因编码属于 T 细胞泛素配体 (TULA) 家族的两个家族成员之一。两个家族成员都可以负向调节 T 细胞信号。该家族成员可以促进 T 细胞中生长因子戒断诱导的细胞凋亡，这可能是通过它与 AIF (一种细胞凋亡诱导因子) 的相互作用而发生的。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2011 年 8 月]

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced Apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

UBASH3A 基因产物(3)

mRNA Protein Name
NM_001001895.3 NP_001001895.1 ubiquitin-associated and SH3 domain-containing protein A isoform 2
NM_001243467.2 NP_001230396.1 ubiquitin-associated and SH3 domain-containing protein A isoform 3
NM_018961.4 NP_061834.1 ubiquitin-associated and SH3 domain-containing protein A isoform 1

UBASH3A 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (283 - 336)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (398 - 595)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
蛋白主名 其他名称

ubiquitin-associated and SH3 domain-containing protein A

T-cell ubiquitin ligand 1

重组 UBASH3A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76687 UBASH3A Protein, Human (His) P57075-2 (A354-N623) ≥95%

关联疾病

疾病名称 别名
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15331 UBASH3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus UBASH3A VGNC VGNC:66755
Mus musculus UBASH3A MGD MGI:1926074
Canis familiaris UBASH3A VGNC VGNC:53047
Bos taurus UBASH3A VGNC VGNC:36574
Macaca mulatta UBASH3A VGNC VGNC:78687
Rattus norvegicus UBASH3A RGD RGD:1310305
Others UBASH3A NCBI
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