S1PR5 - sphingosine-1-phosphate receptor 5 Gene

中文名称：1-磷酸鞘氨醇受体 5

种属: Homo sapiens

同用名: EDG8; S1P5; Edg-8; SPPR-1; SPPR-2

关于 S1PR5

功能概要

溶血鞘脂鞘氨醇 1-磷酸 (S1P) 调节细胞增殖、细胞凋亡、运动和神经突收缩。它的作用既可以在细胞内作为第二信使，也可以在细胞外作为受体配体。 S1P 和结构相关的溶血脂介质溶血磷脂酸 (LPA) 通过一组称为 EDG 受体的 G 蛋白偶联受体向细胞发出信号。一些 EDG 受体 (例如，EDG1；MIM 601974) 是 S1P 受体；其他 (例如，EDG2；MIM 602282) 是 LPA 受体。[OMIM 提供，2008 年 3 月]

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, Apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; Others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]