Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 Gene

中文名称：溶质载体家族 40 (铁调节转运蛋白) ，成员 1

种属: Mus musculus

同用名: MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1

关于 Slc40a1

功能概要

该基因编码的蛋白可启动亚铁跨膜转运体活性；相同的蛋白质结合活性；和肽激素结合活性。参与跨质膜的铁离子输出。作用于多个过程的上游或内部，包括多细胞有机体铁离子稳态；通过 RNA 聚合酶 II 调节转录；和脾小梁的形成。位于基底外侧质膜和突触小泡。以多种结构表达，包括中枢神经系统；胚外成分；泌尿生殖系统；直觉;和淋巴系统腺体。用于研究 4 型血色病。该基因的人类直向同源物与 4 型血色病有关。与人类 SLC40A1（溶质载体家族 40 成员 1）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]