Crebbp - CREB binding protein Gene

中文名称：CREB 结合蛋白

种属: Rattus norvegicus

同用名: CBP; RTS; RSTS

关于 Crebbp

功能概要

该基因编码的蛋白可启动多项功能，包括 SMAD 绑定活动；过氧化物酶体增殖物激活受体结合活性；和转录辅激活因子结合活性。涉及多个过程，包括对可卡因的行为反应；长期记忆;和 NIK/NF-kappaB 信号的正调控。位于核体。转录调节复合物的一部分。该基因的人类直系同源物与 Rubinstein-Taybi 综合征有关；急性淋巴细胞白血病；和急性髓性白血病。与人 CREBBP（CREB 结合蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including SMAD binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including behavioral response to cocaine; long-term memory; and positive regulation of NIK/NF-kappaB signaling. Located in nuclear body. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]