2. Gene
  3. Dnmt3l - DNA (cytosine-5-)-methyltransferase 3-like Gene

Dnmt3l - DNA (cytosine-5-)-methyltransferase 3-like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ecat7; D6Ertd14e

基因 ID: 54427 | 基因类型: protein coding

关于 Dnmt3l

功能概要

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Dnmt3l 基因产物(6)

mRNA Protein Name
NM_001081695.2 NP_001075164.1 DNA (cytosine-5)-methyltransferase 3-like isoform 1
NM_001284197.1 NP_001271126.1 DNA (cytosine-5)-methyltransferase 3-like isoform 1
NM_001284198.1 NP_001271127.1 DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_001284199.1 NP_001271128.1 DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_001284200.1 NP_001271129.1 DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_019448.4 NP_062321.1 DNA (cytosine-5)-methyltransferase 3-like isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: 通过直接分析推断
11934864 MGI
enables enzyme activator activity IDA
IDA: 通过直接分析推断
16543361 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11934864 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
24074865 MGI
acts upstream of or within autosome genomic imprinting IMP
IMP: 通过突变表型推断
11934864 MGI
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: 通过突变表型推断
16920095 MGI
acts upstream of or within epigenetic programing of female pronucleus IMP
IMP: 通过突变表型推断
16920095 MGI
acts upstream of or within genomic imprinting IMP
IMP: 通过突变表型推断
22723905 MGI
involved in genomic imprinting IMP
IMP: 通过突变表型推断
15318244 MGI
involved in male meiosis I IMP
IMP: 通过突变表型推断
15318244 MGI
acts upstream of or within methylation IMP
IMP: 通过突变表型推断
16920095 MGI
involved in negative regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
24074865 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: 通过直接分析推断
30834655 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
16920095 MGI
acts upstream of or within post-embryonic development IDA
IDA: 通过直接分析推断
30834655 MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation IMP
IMP: 通过突变表型推断
25503965 MGI
involved in retrotransposon silencing by heterochromatin formation IMP
IMP: 通过突变表型推断
15318244 MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation IPI
IPI: 通过物理相互作用推断
32674113 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
11934864 MGI
involved in spermatogenesis IMP
IMP: 通过突变表型推断
15318244 MGI
involved in stem cell differentiation IMP
IMP: 通过突变表型推断
24074865 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESC/E(Z) complex IDA
IDA: 通过直接分析推断
24074865 MGI
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
16543361 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
16543361 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
11934864 MGI
located in nucleus IDA
IDA: 通过直接分析推断
27856912 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA (cytosine-5)-methyltransferase 3-like

Dnmt3l 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dnmt3l Q9CWR8 Dnmt3a Mus musculus O88508-1
Anti Tag CoIP
17687327
种属间
Dnmt3l Q9CWR8 EZH2 Homo sapiens Q15910
Anti Bait CoIP
24074865
种属内
Dnmt3l Q9CWR8 Dnmt3b Mus musculus O88509
Anti Bait CoIP
24074865
种属内
Dnmt3l Q9CWR8 Dnmt3b Mus musculus O88509
GMS
24074865
种属内
Dnmt3l Q9CWR8 Dnmt3b Mus musculus O88509
Anti Tag CoIP
17687327
种属内
Dnmt3l Q9CWR8 Ezh2 Mus musculus Q61188
Anti Bait CoIP
24074865
种属内
Dnmt3l Q9CWR8 Ezh2 Mus musculus Q61188
Anti Tag CoIP
24074865
种属内
Dnmt3l Q9CWR8 Dnmt3a Mus musculus O88508
Anti Bait CoIP
24074865
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03913 DNMT3L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dnmt3l NCBI NCBI:29947
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z