1. Gene
  2. GFOD1 - glucose-fructose oxidoreductase domain containing 1 Gene

GFOD1 - glucose-fructose oxidoreductase domain containing 1 Gene

中文名称:含葡萄糖-果糖氧化还原酶结构域 1

种属: Homo sapiens

同用名: ADG-90; C6orf114

基因 ID: 54438 | 基因类型: protein coding

关于 GFOD1

Cytogenetic location: 6p24.1-p23 Genomic coordinates (GRCh38): 6:13,357,830-13,487,600 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in brain (RPKM 7.3), fat (RPKM 5.7) and 21 other tissues.

功能概要

预测启用核苷酸结合活性和氧化还原酶活性。预测位于细胞外区域。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable nucleotide binding activity and oxidoreductase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

GFOD1 基因产物(4)

mRNA Protein Name
NM_001242628.2 NP_001229557.1 glucose-fructose oxidoreductase domain-containing protein 1 isoform 2
NM_001242629.2 NP_001229558.1 glucose-fructose oxidoreductase domain-containing protein 1 isoform 3 precursor
NM_001242630.2 NP_001229559.1 glucose-fructose oxidoreductase domain-containing protein 1 isoform 2
NM_018988.4 NP_061861.1 glucose-fructose oxidoreductase domain-containing protein 1 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GFOD1 蛋白结构

GFO_IDH_MocA

GFO_IDH_MocA: Oxidoreductase family, NAD-binding Rossmann fold (5 - 112)

GFO_IDH_MocA_C

GFO_IDH_MocA_C: Oxidoreductase family, C-terminal alpha/beta domain (132 - 198)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

glucose-fructose oxidoreductase domain-containing protein 1

GFOD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GFOD1 Q9NXC2 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra GFOD1 Q9NXC2 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra GFOD1 Q9NXC2 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra GFOD1 Q9NXC2 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra GFOD1 Q9NXC2 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra GFOD1 Q9NXC2 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra GFOD1 Q9NXC2 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra GFOD1 Q9NXC2 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra GFOD1 Q9NXC2 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra GFOD1 Q9NXC2 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra GFOD1 Q9NXC2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra GFOD1 Q9NXC2 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra GFOD1 Q9NXC2 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra GFOD1 Q9NXC2 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra GFOD1 Q9NXC2 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra GFOD1 Q9NXC2 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra GFOD1 Q9NXC2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra GFOD1 Q9NXC2 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra GFOD1 Q9NXC2 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra GFOD1 Q9NXC2 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra GFOD1 Q9NXC2 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra GFOD1 Q9NXC2 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra GFOD1 Q9NXC2 KRT31 Homo sapiens Q15323
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

Mlc

Van Der Knaap Disease

Lvm

Leukoencephalopathy With Swelling And Cysts

Megalencephaly-Cystic Leukodystrophy

Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome

Infantile Leukoencephalopathy And Megalencephaly

Leukoencephalopathy With Swelling And A Discrepantly Mild Course

Vacuolating Leukoencephalopathy

Megalencephalic Leukodystrophy

Megalencephaly-Cystic Leukodystrophy Syndrome

Van Der Knaap Syndrome

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GFOD1 MGD MGI:2145304
Felis catus GFOD1 VGNC VGNC:102429
Macaca mulatta GFOD1 VGNC VGNC:72756
Canis familiaris GFOD1 VGNC VGNC:41185
Bos taurus GFOD1 VGNC VGNC:106753
Rattus norvegicus GFOD1 RGD RGD:1311507