2. Gene
  3. PON3 - paraoxonase 3 Gene

PON3 - paraoxonase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：对氧磷酶 3

种属: Homo sapiens

基因 ID: 5446 | 基因类型: protein coding

关于 PON3

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,359,872-95,396,375 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4).

功能概要

该基因是对氧磷酶家族的一员，与其他两个家族成员位于 7 号染色体上的一个簇中。编码的蛋白质被分泌到血液中并与高密度脂蛋白 (HDL) 结合。该蛋白质还可以快速水解内酯，并可以抑制低密度脂蛋白 (LDL) 的氧化，这种功能被认为可以减缓动脉粥样硬化的发生和发展。已经描述了编码不同蛋白质同种型的可变剪接变体；然而，只有一个得到了充分的表征。[RefSeq 提供，2008 年 7 月]

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the Other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

PON3 基因产物(1)

mRNA Protein Name
NM_000940.3 NP_000931.1 serum paraoxonase/lactonase 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acyl-L-homoserine-lactone lactonohydrolase activity IDA
IDA: 通过直接分析推断
15772423 GOA
enables arylesterase activity IDA
IDA: 通过直接分析推断
15772423 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
15772423 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carboxylic acid catabolic process IDA
IDA: 通过直接分析推断
15772423 GOA
involved in lactone catabolic process IDA
IDA: 通过直接分析推断
15772423 GOA
involved in regulation of cellular response to drug IDA
IDA: 通过直接分析推断
15772423 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PON3 蛋白结构

Arylesterase

Arylesterase: Arylesterase (167 - 252)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

serum paraoxonase/lactonase 3

arylesterase 3

重组 PON3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74623 PON3 Protein, Human (S50N, sf9, His) Q15166-1 (M1-L354) ≥95%

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Acute Tympanitis

Acute Myringitis
Atherosclerosis Susceptibility

Atherosclerosis

Atherosclerosis, Susceptibility To

ATHS

Atherogenic Lipoprotein Phenotype

Alp

Arteriosclerosis
Persian Gulf Syndrome

Gulf War Syndrome
Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases
Coronary Heart Disease 1

Coronary Heart Disease

Coronary Heart Disease, Susceptibility To, 1

Chds1

Coronary Heart Disease, Susceptibility To

CHD

Heart, Coronary, Disease, Susceptibility To, Type 1

Coronary Arteriosclerosis

Coronary Artery Disease
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10874 PON3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PON3 MGD MGI:106686
Felis catus PON3 VGNC VGNC:68959
Rattus norvegicus PON3 RGD RGD:1302965
Bos taurus PON3 VGNC VGNC:33162
Canis familiaris PON3 VGNC VGNC:44814
Macaca mulatta PON3 VGNC VGNC:76221
Others PON3 NCBI
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