1. Gene
  2. SDK2 - sidekick cell adhesion molecule 2 Gene

SDK2 - sidekick cell adhesion molecule 2 Gene

中文名称:搭档细胞粘附分子 2

种属: Homo sapiens

基因 ID: 54549 | 基因类型: protein coding

关于 SDK2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,334,384-73,644,445 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 36 paralogues. Biased expression in testis (RPKM 6.4), spleen (RPKM 1.7) and 8 other tissues.

功能概要

该基因编码的蛋白质是免疫球蛋白超家族的成员。该蛋白质包含两个免疫球蛋白结构域和十三个纤连蛋白 III 型结构域。 III 型纤连蛋白结构域存在于细胞外和细胞内蛋白质中,并且已知串联重复包含 DNA、肝素和细胞表面的结合位点。这种蛋白质和同源小鼠序列与果蝇 sidekick 基因产物非常相似,但该超家族成员的具体功能尚不清楚。已观察到该基因位点可变剪接的证据,但尚未确定其他变体的全长性质。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008]

SDK2 基因产物(1)

mRNA Protein Name
NM_001144952.2 NP_001138424.1 protein sidekick-2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SDK2 蛋白结构

ig

ig: Immunoglobulin domain (41 - 93)

I-set

I-set: Immunoglobulin I-set domain (115 - 195)

Ig_2

Ig_2: Immunoglobulin domain (218 - 294)

I-set

I-set: Immunoglobulin I-set domain (308 - 397)

I-set

I-set: Immunoglobulin I-set domain (402 - 492)

I-set

I-set: Immunoglobulin I-set domain (497 - 586)

fn3

fn3: Fibronectin type III domain (600 - 677)

fn3

fn3: Fibronectin type III domain (693 - 779)

fn3

fn3: Fibronectin type III domain (794 - 883)

fn3

fn3: Fibronectin type III domain (897 - 979)

fn3

fn3: Fibronectin type III domain (995 - 1083)

fn3

fn3: Fibronectin type III domain (1099 - 1187)

fn3

fn3: Fibronectin type III domain (1202 - 1288)

fn3

fn3: Fibronectin type III domain (1303 - 1385)

fn3

fn3: Fibronectin type III domain (1408 - 1488)

fn3

fn3: Fibronectin type III domain (1504 - 1611)

fn3

fn3: Fibronectin type III domain (1626 - 1712)

fn3

fn3: Fibronectin type III domain (1725 - 1805)

fn3

fn3: Fibronectin type III domain (1827 - 1912)

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  • 2172 a.a.
蛋白主名 其他名称

protein sidekick-2

sidekick homolog 2

SDK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SDK2 Q58EX2 VMAC Homo sapiens Q2NL98 32296183
种属内
SDK2 Q58EX2 VMAC Homo sapiens Q2NL98 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Patellar Tendinitis

Patellar Tendonitis

Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Brachyolmia

Brachyrachia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SDK2 VGNC VGNC:64954
Mus musculus SDK2 MGD MGI:2443847
Macaca mulatta SDK2 VGNC VGNC:99225
Rattus norvegicus SDK2 RGD RGD:1310397
Canis familiaris SDK2 VGNC VGNC:45954
Bos taurus SDK2 VGNC VGNC:34394