2. Gene
  3. PARP14 - poly(ADP-ribose) polymerase family member 14 Gene

PARP14 - poly(ADP-ribose) polymerase family member 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 14

种属: Homo sapiens

同用名: BAL2; ARTD8; pART8; PARP-14

基因 ID: 54625 | 基因类型: protein coding

关于 PARP14

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,680,839-122,730,840 (from NCBI)

This gene has 7 transcripts (splice variants), 295 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues.

功能概要

该基因编码聚 (ADP-核糖) 聚合酶 (PARP) 蛋白家族的成员。编码的抗凋亡蛋白可以调节有氧糖酵解并促进癌细胞的存活。已在多种肿瘤类型中报道了该基因表达增加。[RefSeq 提供，2016 年 7 月]

This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of Cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

PARP14 基因产物(3)

mRNA Protein Name
NM_017554.3 NP_060024.2 protein mono-ADP-ribosyltransferase PARP14
XM_011512929.3 XP_011511231.1 protein mono-ADP-ribosyltransferase PARP14 isoform X1
XR_007095695.1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+ binding IMP
IMP: 通过突变表型推断
16061477 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
18851833 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
27796300 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: 通过突变表型推断
16061477 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
27796300 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23473667 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
27796300 GOA
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
27796300 GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein IMP
IMP: 通过突变表型推断
27796300 GOA
involved in positive regulation of interleukin-4-mediated signaling pathway IMP
IMP: 通过突变表型推断
27796300 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: 通过突变表型推断
27796300 GOA
involved in protein poly-ADP-ribosylation IMP
IMP: 通过突变表型推断
16061477 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27796300 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP14 蛋白结构

Macro

Macro: Macro domain (820 - 936)

Macro

Macro: Macro domain (1044 - 1147)

Macro

Macro: Macro domain (1245 - 1346)

WWE

WWE: WWE domain (1536 - 1586)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (1625 - 1800)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1801 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP14

ADP-ribosyltransferase diphtheria toxin-like 8

B-aggressive lymphoma 2

b aggressive lymphoma protein 2

collaborator of STAT6

poly [ADP-ribose] polymerase 14

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 44

SCA44
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136979 RBN012759 Inhibitor 99.80% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-108708 GeA-69 Inhibitor 99.91% 否
HY-117889 PARP14 inhibitor H10 Inhibitor 98.04% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-W294889 OUL245 Inhibitor / 否
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / 否
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PARP14 VGNC VGNC:84054
Felis catus PARP14 VGNC VGNC:102797
Mus musculus PARP14 MGD MGI:1919489
Rattus norvegicus PARP14 RGD RGD:1310490
Canis familiaris PARP14 VGNC VGNC:53082
Others PARP14 NCBI
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