2. Gene
  3. DIRAS2 - DIRAS family GTPase 2 Gene

DIRAS2 - DIRAS family GTPase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DIRAS 家族 GTPase 2

种属: Homo sapiens

同用名: Di-Ras2

基因 ID: 54769 | 基因类型: protein coding

关于 DIRAS2

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:90,609,832-90,642,824 (from NCBI)

This gene has 3 transcripts (splice variants), 156 orthologues and 35 paralogues. Biased expression in brain (RPKM 52.9) and gall bladder (RPKM 3.4).

功能概要

DIRAS2 属于功能多样的 Ras 的一个独特分支 (参见 HRAS；MIM 190020) 单体 GTP 酶超家族。[OMIM 提供，2004 年 4 月]

DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

DIRAS2 基因产物(1)

mRNA Protein Name
NM_017594.5 NP_060064.2 GTP-binding protein Di-Ras2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
12194967 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
12194967 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
12194967 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12194967 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DIRAS2 蛋白结构

Ras

Ras: Ras family (10 - 167)

  • 0
  • 100
  • 199 a.a.
蛋白主名 其他名称

GTP-binding protein Di-Ras2

DIRAS family, GTP-binding RAS-like 2

DIRAS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DIRAS2 Q96HU8 UNC45A Homo sapiens Q9H3U1
Y2H Prey Pooling
32296183
种属内
DIRAS2 Q96HU8 UNC45A Homo sapiens Q9H3U1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Straussler-Scheinker Syndrome

Prion Dementia

Cerebral Amyloid Angiopathy, Prnp-Related

GSD

Gss

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns

Amyloidosis, Cerebral, With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type

Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type

Amyloidosis Cerebral With Spongiform Encephalopathy

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System

Encephalopathy Subacute Spongiform Gerstmann-Straussler Type

Gssd

Gerstmann Straussler Scheinker Syndrome

Cerebral Amyloidosis With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy Gerstmann-Straussler Type

Gluthathione Synthetase Deficiency

Gerstmann Straussler Syndrome
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03776 DIRAS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DIRAS2 VGNC VGNC:39961
Mus musculus DIRAS2 MGD MGI:1915453
Bos taurus DIRAS2 VGNC VGNC:28070
Felis catus DIRAS2 VGNC VGNC:61498
Macaca mulatta DIRAS2 VGNC VGNC:71673
Rattus norvegicus DIRAS2 RGD RGD:1305580
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