ERCC6L - ERCC excision repair 6 like, spindle assembly checkpoint helicase Gene

中文名称：ERCC 切除修复 6 样，纺锤体组装检查点解旋酶

种属: Homo sapiens

同用名: PICH; RAD26L

关于 ERCC6L

功能概要

该基因编码 SWItch/Sucrose Non-Fermentable (SWI/SNF2) 蛋白家族的成员，并包含一个 SNF2 样 ATPase 结构域和一个 PICH 家族结构域。这个 SWI/SNF 蛋白家族成员的一个显着特征是在分裂间期，该蛋白被排除在细胞核之外，只有在核膜破裂后才与染色质结合。这种蛋白质是一种 DNA 转位酶，被认为可以结合暴露于拉伸力 (例如有丝分裂纺锤体施加的拉伸力) 的双链 DNA。这种蛋白质与核糖体 DNA 和超细 DNA 桥 (UFB) 结合，这些精细结构在后期在某些位点 (如脆弱位点、端粒和着丝粒) 连接姐妹染色单体。该基因是有丝分裂期间姐妹染色单体忠实分离所必需的，而该蛋白的 ATP 酶活性是胞质分裂前 UFB 分解所必需的。[RefSeq 提供，2017 年 5 月]

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]