RNF43 - ring finger protein 43 Gene

中文名称：无名指蛋白 43

种属: Homo sapiens

同用名: URCC; SSPCS; RNF124

基因 ID: 54894 | 基因类型: protein coding

关于 RNF43

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,352,500-58,417,534 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 105 phenotypes. Broad expression in duodenum (RPKM 7.1), colon (RPKM 6.1) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种 RING 型 E3 泛素连接酶，预计包含一个跨膜结构域、一个蛋白酶相关结构域、一个胞外结构域和一个细胞质 RING 结构域。这种蛋白质被认为负向调节 Wnt 信号，该基因的表达导致卷曲受体的泛素化增加，改变它们的亚细胞分布，导致这些受体的表面水平降低。该基因的突变已在多种肿瘤细胞中报道，包括结直肠癌和子宫内膜癌。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 3 月]

The protein encoded by this gene is a RING-type E3 ubiquitin Ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of Frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

RNF43 基因产物(3)

mRNA	Protein	Name
NM_001305544.2	NP_001292473.1	E3 ubiquitin-protein ligase RNF43 isoform 1 precursor
NM_001305545.1	NP_001292474.1	E3 ubiquitin-protein ligase RNF43 isoform 2
NM_017763.6	NP_060233.3	E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables frizzled binding	IPI IPI: 通过物理相互作用推断	22895187	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18313049	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	22575959	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Wnt receptor catabolic process	IDA IDA: 通过直接分析推断	22895187	GOA
involved in negative regulation of Wnt signaling pathway	IMP IMP: 通过突变表型推断	22575959	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	22575959	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	22895187	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	22575959	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF43 蛋白结构

zf-RING_2

0
200
400
600
783 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase RNF43

RING-type E3 ubiquitin transferase RNF43

RNF43 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RNF43	Q68DV7	MYADM	Homo sapiens	Q96S97	Anti Tag CoIP	33961781
种属内	RNF43	Q68DV7	UBE2D2	Homo sapiens	P62837	Enzymatic Study	18313049
种属内	RNF43	Q68DV7	UBE2D3	Homo sapiens	P61077	Enzymatic Study	18313049
种属内	RNF43	Q68DV7	UBE2D3	Homo sapiens	P61077	Y2H Array	19690564
种属内	RNF43	Q68DV7	AKAP8L	Homo sapiens	Q9ULX6	Y2H	18313049
种属内	RNF43	Q68DV7	AKAP8L	Homo sapiens	Q9ULX6	Anti Tag CoIP	18313049
种属内	RNF43	Q68DV7	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	18313049

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RNF43 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76007	RNF43 Protein, Human (HEK293, Fc)	Q68DV7 (G24-Y197)	≥95%
HY-P76008	RNF43 Protein, Human (HEK293, His)	Q68DV7-1/NP_060233.3 (G24-Y197)	≥95%

关联疾病

疾病名称

别名

Sessile Serrated Polyposis Cancer Syndrome

SSPCS	Serrated Polyposis Syndrome
Hyperplastic Polyposis Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Uterine Corpus Endometrial Carcinoma

Pancreatoblastoma

Hereditary Mixed Polyposis Syndrome

Hmps

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Ovarian Cystadenocarcinoma

Cystadenocarcinoma Of Ovary

Cystadenocarcinoma Of The Ovary

Pancreatic Mucinous Cystadenoma

Pancreatic Mucinous Cystic Neoplasm

Pancreatic Mucinous-Cystic Neoplasm

Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma	Cystadenoma Serous
Cystadenoma, Serous

Ovary Adenocarcinoma

Ovarian Adenocarcinoma	Adenocarcinoma Of The Ovary
Ovarian Adenoacanthoma	Adenocarcinoma Of Ovary

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12093	RNF43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RNF43	RGD	RGD:1305204
Mus musculus	RNF43	MGD	MGI:2442609
Macaca mulatta	RNF43	VGNC	VGNC:99221
Canis familiaris	RNF43	VGNC	VGNC:45671
Felis catus	RNF43	VGNC	VGNC:99434
Bos taurus	RNF43	VGNC	VGNC:34068
Others	RNF43	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RNF43 - ring finger protein 43 Gene

关于 RNF43

功能概要

RNF43 基因产物(3)

RNF43 蛋白结构

RNF43 蛋白互作信息

重组 RNF43 蛋白

关联疾病

直系同源

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RNF43 - ring finger protein 43 Gene

关于 RNF43

功能概要

RNF43 基因产物(3)

RNF43 蛋白结构

RNF43 蛋白互作信息

重组 RNF43 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z