2. Gene
  3. MYADM - myeloid associated differentiation marker Gene

MYADM - myeloid associated differentiation marker Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：骨髓相关分化标志物

种属: Homo sapiens

同用名: SB135

基因 ID: 91663 | 基因类型: protein coding

关于 MYADM

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,865,628-53,876,435 (from NCBI)

This gene has 11 transcripts (splice variants), 379 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues.

功能概要

参与多个过程，包括异型细胞间粘附的负调控；大分子代谢过程的负调控；蛋白激酶 C 信号传导的负调控。位于几种细胞成分中，包括皮质肌动蛋白细胞骨架；膜筏；和荷叶边。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

MYADM 基因产物(12)

mRNA Protein Name
NM_001020818.2 NP_001018654.1 myeloid-associated differentiation marker
NM_001020819.3 NP_001018655.1 myeloid-associated differentiation marker
NM_001020820.3 NP_001018656.1 myeloid-associated differentiation marker
NM_001020821.2 NP_001018657.1 myeloid-associated differentiation marker
NM_001290188.2 NP_001277117.1 myeloid-associated differentiation marker
NM_001290189.1 NP_001277118.1 myeloid-associated differentiation marker
NM_001290190.2 NP_001277119.1 myeloid-associated differentiation marker
NM_001290191.2 NP_001277120.1 myeloid-associated differentiation marker
NM_001290192.2 NP_001277121.1 myeloid-associated differentiation marker
NM_001290193.2 NP_001277122.1 myeloid-associated differentiation marker
NM_001290194.2 NP_001277123.1 myeloid-associated differentiation marker
NM_138373.5 NP_612382.1 myeloid-associated differentiation marker
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in cell-cell junction maintenance IMP
IMP: 通过突变表型推断
23264465 GOA
involved in establishment of endothelial barrier IMP
IMP: 通过突变表型推断
23264465 GOA
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
23264465 GOA
involved in membrane raft organization IMP
IMP: 通过突变表型推断
21325632 GOA
involved in negative regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
23264465 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
23264465 GOA
involved in negative regulation of heterotypic cell-cell adhesion IDA
IDA: 通过直接分析推断
23264465 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
21325632 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
21325632 GOA
involved in protein localization to plasma membrane raft IMP
IMP: 通过突变表型推断
21325632 GOA
NOT involved in regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
21325632 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23264465 GOA
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
21325632 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
21325632 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23264465 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
21325632 GOA
located in ruffle IDA
IDA: 通过直接分析推断
21325632 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYADM 蛋白结构

MARVEL

MARVEL: Membrane-associating domain (32 - 154)

MARVEL

MARVEL: Membrane-associating domain (169 - 312)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
蛋白主名 其他名称

myeloid-associated differentiation marker

myeloid upregulated protein

MYADM 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MYADM Q96S97 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra MYADM Q96S97 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
Intra MYADM Q96S97 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra MYADM Q96S97 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra MYADM Q96S97 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra MYADM Q96S97 ARF6 Homo sapiens P62330
Anti Tag CoIP
28514442
Intra MYADM Q96S97 ARF6 Homo sapiens P62330
Anti Tag CoIP
33961781
Intra MYADM Q96S97 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra MYADM Q96S97 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra MYADM Q96S97 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra MYADM Q96S97 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra MYADM Q96S97 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08868 MYADM Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MYADM VGNC VGNC:68368
Mus musculus MYADM MGD MGI:1355332
Rattus norvegicus MYADM RGD RGD:727835
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