2. Gene
  3. PARP16 - poly(ADP-ribose) polymerase family member 16 Gene

PARP16 - poly(ADP-ribose) polymerase family member 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 16

种属: Homo sapiens

同用名: ARTD15; pART15; C15orf30

基因 ID: 54956 | 基因类型: protein coding

关于 PARP16

This gene has 6 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues.

功能概要

启用激酶结合活性；戊糖基转移酶活性；和蛋白质丝氨酸/苏氨酸激酶激活剂活性。参与多个过程，包括 IRE1 介导的未折叠蛋白反应；蛋白丝氨酸/苏氨酸激酶活性的正调节；和蛋白质 ADP-核糖基化。位于内质网管状网络和核膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PARP16 基因产物(3)

mRNA Protein Name
NM_001316943.2 NP_001303872.1 protein mono-ADP-ribosyltransferase PARP16 isoform 2
NM_001316944.2 NP_001303873.1 protein mono-ADP-ribosyltransferase PARP16 isoform 3
NM_017851.6 NP_060321.3 protein mono-ADP-ribosyltransferase PARP16 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: 通过突变表型推断
22701565 GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein-lysine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
23103912 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22701565 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: 通过突变表型推断
23103912 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in IRE1-mediated unfolded protein response IMP
IMP: 通过突变表型推断
23103912 GOA
involved in endoplasmic reticulum unfolded protein response IMP
IMP: 通过突变表型推断
23103912 GOA
involved in negative regulation of cytoplasmic translation IDA
IDA: 通过直接分析推断
34314702 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
25043379 GOA
involved in protein auto-ADP-ribosylation IMP
IMP: 通过突变表型推断
22701565 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IMP
IMP: 通过突变表型推断
23103912 GOA
located in endoplasmic reticulum tubular network IMP
IMP: 通过突变表型推断
22701565 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
22701565 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP16 蛋白结构

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (95 - 272)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP16

ADP-ribosyltransferase diphtheria toxin-like 15

PARP16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PARP16 Q8N5Y8 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
种属内
PARP16 Q8N5Y8 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150221 DB008 Inhibitor 98.78% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PARP16 MGD MGI:2446133
Macaca mulatta PARP16 VGNC VGNC:84416
Bos taurus PARP16 VGNC VGNC:53576
Rattus norvegicus PARP16 RGD RGD:1306243
Felis catus PARP16 VGNC VGNC:80892
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