UCKL1 - uridine-cytidine kinase 1 like 1 Gene

中文名称：尿苷胞苷激酶 1 样 1

种属: Homo sapiens

同用名: UCK1L; URKL1

关于 UCKL1

功能概要

该基因编码的蛋白质是尿苷激酶。尿苷激酶催化尿苷磷酸化为尿苷一磷酸。该蛋白已被证明可与 Epstein-Barr 核抗原 3 以及自然杀伤细胞裂解相关分子结合。自然杀伤细胞裂解相关分子的存在增强了这种蛋白质的泛素化。此外，在自然杀伤细胞裂解相关分子存在的情况下，蛋白质水平会降低，这表明与自然杀伤细胞裂解相关分子的结合会导致泛素化和随后的该蛋白质降解。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 11 月]

The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]