2. Gene
  3. USP47 - ubiquitin specific peptidase 47 Gene

USP47 - ubiquitin specific peptidase 47 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 47

种属: Homo sapiens

同用名: TRFP

基因 ID: 55031 | 基因类型: protein coding

关于 USP47

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,841,972-11,961,887 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 11.7), heart (RPKM 10.2) and 25 other tissues.

功能概要

启用 WD40 重复结构域结合活性和硫醇依赖性去泛素化酶。参与多个过程，包括单泛素化蛋白质去泛素化；有丝分裂细胞周期 G2/M 转换的负调控；氮化合物代谢过程的负调控。位于细胞质中。 SCF 泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables WD40-repeat domain binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

USP47 基因产物(16)

mRNA Protein Name
NM_001282659.2 NP_001269588.1 ubiquitin carboxyl-terminal hydrolase 47 isoform a
NM_001330208.2 NP_001317137.1 ubiquitin carboxyl-terminal hydrolase 47 isoform c
NM_001372091.1 NP_001359020.1 ubiquitin carboxyl-terminal hydrolase 47 isoform d
NM_001372092.1 NP_001359021.1 ubiquitin carboxyl-terminal hydrolase 47 isoform e
NM_001372093.1 NP_001359022.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372094.1 NP_001359023.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372095.1 NP_001359024.1 ubiquitin carboxyl-terminal hydrolase 47 isoform g
NM_001372096.1 NP_001359025.1 ubiquitin carboxyl-terminal hydrolase 47 isoform h
NM_001372097.1 NP_001359026.1 ubiquitin carboxyl-terminal hydrolase 47 isoform i
NM_001372098.1 NP_001359027.1 ubiquitin carboxyl-terminal hydrolase 47 isoform j
NM_001372099.1 NP_001359028.1 ubiquitin carboxyl-terminal hydrolase 47 isoform k
NM_001372100.1 NP_001359029.1 ubiquitin carboxyl-terminal hydrolase 47 isoform l
NM_001372101.1 NP_001359030.1 ubiquitin carboxyl-terminal hydrolase 47 isoform n
NM_001372102.1 NP_001359031.1 ubiquitin carboxyl-terminal hydrolase 47 isoform o
NM_001372103.1 NP_001359032.1 ubiquitin carboxyl-terminal hydrolase 47 isoform m
NM_017944.4 NP_060414.3 ubiquitin carboxyl-terminal hydrolase 47 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables WD40-repeat domain binding IPI
IPI: 通过物理相互作用推断
19966869 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
21362556 GOA
enables deubiquitinase activity IDA
IDA: 通过直接分析推断
26169834 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21362556 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
21362556 GOA
involved in base-excision repair IMP
IMP: 通过突变表型推断
21362556 GOA
involved in monoubiquitinated protein deubiquitination IDA
IDA: 通过直接分析推断
21362556 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19966869 GOA
involved in negative regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
19966869 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19966869 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
19966869 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
26169834 GOA
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
19966869 GOA
involved in response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
19966869 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SCF ubiquitin ligase complex IDA
IDA: 通过直接分析推断
19966869 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21362556 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
36749823 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP47 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (187 - 561)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1375 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 47

Trf (TATA binding protein-related factor)-proximal homolog

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13865 P 22077 Inhibitor 98.07% 否
HY-112937 GNE-6640 Inhibitor 99.91% 否
HY-13487 USP7/USP47 inhibitor Inhibitor 98.63% 否
HY-134817 USP7-IN-8 Inhibitor 99.04% 否
HY-RS15558 USP47 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-111166 USP7/USP47 inhibitor 1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USP47 RGD RGD:1310411
Bos taurus USP47 VGNC VGNC:36732
Felis catus USP47 VGNC VGNC:66890
Mus musculus USP47 MGD MGI:1922246
Macaca mulatta USP47 VGNC VGNC:79230
Canis familiaris USP47 VGNC VGNC:48198
Others USP47 NCBI
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