2. Gene
  3. TAPBPL - TAP binding protein like Gene

TAPBPL - TAP binding protein like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TAP 结合蛋白

种属: Homo sapiens

同用名: TAPBPR; TAPBP-R

基因 ID: 55080 | 基因类型: protein coding

关于 TAPBPL

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,451,649-6,472,006 (from NCBI)

This gene has 8 transcripts (splice variants), 182 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 8.1), small intestine (RPKM 7.3) and 25 other tissues.

功能概要

Tapasin，或 TAPBP (MIM 601962) ，是可变常数 Ig 超家族的成员，它将主要组织相容性复合体 (MHC) I 类分子连接到内质网 (ER) 中与抗原加工相关的转运体 (TAP；参见 MIM 170260) ) . TAPBP 基因位于染色体 6p21.3 上的 MHC 复合体附近。 TAPBPL 是位于染色体 12p13.3 上的 Ig 超家族成员，该区域与 MHC 有点相似。[OMIM 提供，2008 年 3 月]

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

TAPBPL 基因产物(2)

mRNA Protein Name
NM_001351355.2 NP_001338284.1 tapasin-related protein isoform 2
NM_018009.5 NP_060479.3 tapasin-related protein isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class I protein complex binding IDA
IDA: 通过直接分析推断
23401559 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23401559 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I IDA
IDA: 通过直接分析推断
23401559 GOA
involved in peptide antigen assembly with MHC class I protein complex IDA
IDA: 通过直接分析推断
26869717 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23401559 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAPBPL 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (194 - 294)

C1-set

C1-set: Immunoglobulin C1-set domain (317 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
蛋白主名 其他名称

tapasin-related protein

TAP binding protein related

TAPBPL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TAPBPL Q9BX59 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra TAPBPL Q9BX59 HLA-B Homo sapiens P01889
Anti Bait CoIP
26439010
Intra TAPBPL Q9BX59 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra TAPBPL Q9BX59 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra TAPBPL Q9BX59 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra TAPBPL Q9BX59 PM20D2 Homo sapiens Q8IYS1
Y2H Array
32296183
Intra TAPBPL Q9BX59 PM20D2 Homo sapiens Q8IYS1
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra TAPBPL Q9BX59 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra TAPBPL Q9BX59 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 HLA-A Homo sapiens P01892
Anti Bait CoIP
26439010
Intra TAPBPL Q9BX59 HLA-A Homo sapiens P01892
Anti Bait CoIP
24163410
Intra TAPBPL Q9BX59 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra TAPBPL Q9BX59 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra TAPBPL Q9BX59 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra TAPBPL Q9BX59 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Ataxia 1, Autosomal Dominant

SPAX1

Ataxia, Spastic, 1, Autosomal Dominant

Autosomal Dominant Spastic Ataxia Type 1

Ataxia, Spastic, Type 1, Autosomal Dominant
Spastic Ataxia 1
Myasthenic Syndrome, Congenital, 25, Presynaptic

CMS25

Myasthenic Syndrome, Congenital, 25
Congenital Myasthenic Syndrome

Congenital Myasthenia

Congenital Myasthenic Syndromes

Cms

Myasthenic Syndromes, Congenital

Myasthenic Syndromes Congenital

Myasthenic Syndrome, Congenital

Congenital Myasthenic Syndrome Ib

Congenital And Developmental Myasthenia

Developmental Myasthenia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14204 TAPBPL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TAPBPL MGD MGI:2384853
Felis catus TAPBPL VGNC VGNC:65953
Rattus norvegicus TAPBPL RGD RGD:1307893
Canis familiaris TAPBPL VGNC VGNC:47107
Bos taurus TAPBPL VGNC VGNC:35600
Macaca mulatta TAPBPL NCBI NCBI:712626
Others TAPBPL NCBI
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