SLC6A15 - solute carrier family 6 member 15 Gene

中文名称：溶质载体家族 6 成员 15

种属: Homo sapiens

同用名: V7-3; NTT73; SBAT1; hv7-3

基因 ID: 55117 | 基因类型: protein coding

关于 SLC6A15

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:84,859,491-84,912,799 (from NCBI)

This gene has 45 transcripts (splice variants), 219 orthologues and 19 paralogues. Biased expression in brain (RPKM 5.0), placenta (RPKM 1.2) and 3 other tissues.

功能概要

该基因编码转运中性氨基酸的溶质载体家族 6 蛋白家族的成员。编码的蛋白质被认为在神经元氨基酸转运中发挥作用 (PMID：16185194) ，并且可能与重度抑郁症 (PMID：21521612) 有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the solute carrier family 6 protein family which transports neutral Amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

SLC6A15 基因产物(3)

mRNA	Protein	Name
NM_001146335.3	NP_001139807.1	sodium-dependent neutral amino acid transporter B(0)AT2 isoform 3
NM_018057.7	NP_060527.2	sodium-dependent neutral amino acid transporter B(0)AT2 isoform 2
NM_182767.6	NP_877499.1	sodium-dependent neutral amino acid transporter B(0)AT2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables branched-chain amino acid:sodium symporter activity	IDA IDA: 通过直接分析推断	16226721	GOA
enables neutral L-amino acid:sodium symporter activity	IDA IDA: 通过直接分析推断	16226721	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in neutral amino acid transport	IDA IDA: 通过直接分析推断	16226721	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	16226721	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC6A15 蛋白结构

SNF

0
200
400
600
730 a.a.

蛋白主名

其他名称

sodium-dependent neutral amino acid transporter B(0)AT2

homolog of rat orphan transporter v7-3

SLC6A15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC6A15	Q9H2J7	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
种属内	SLC6A15	Q9H2J7	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 3

Epileptic Encephalopathy, Early Infantile, 3	DEE3
Eiee3	Early Myoclonic Encephalopathy
Developmental And Epileptic Encephalopathy, 3	Early Infantile Epileptic Encephalopathy 3
Eme	Neonatal Epilepsy With Suppression-Burst Pattern
Encephalopathy, Epileptic, Early Infantile, Type 3

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Retinitis Pigmentosa 68

RP68	Retinitis Pigmentosa, Type 68

Iminoglycinuria

Iminoglycinuria, Digenic

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13301	SLC6A15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SLC6A15	RGD	RGD:628664
Mus musculus	SLC6A15	MGD	MGI:2143484
Felis catus	SLC6A15	VGNC	VGNC:65411
Canis familiaris	SLC6A15	VGNC	VGNC:46458
Bos taurus	SLC6A15	VGNC	VGNC:34918
Macaca mulatta	SLC6A15	VGNC	VGNC:77691

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC6A15 - solute carrier family 6 member 15 Gene

关于 SLC6A15

功能概要

SLC6A15 基因产物(3)

SLC6A15 蛋白结构

SLC6A15 蛋白互作信息

关联疾病

直系同源

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SLC6A15 - solute carrier family 6 member 15 Gene

关于 SLC6A15

功能概要

SLC6A15 基因产物(3)

SLC6A15 蛋白结构

SLC6A15 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z