MAP1S - microtubule associated protein 1S Gene

中文名称：微管相关蛋白 1S

种属: Homo sapiens

同用名: MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1

基因 ID: 55201 | 基因类型: protein coding

关于 MAP1S

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,719,480-17,734,513 (from NCBI)

This gene has 21 transcripts (splice variants), 242 orthologues and 2 paralogues. Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues.

功能概要

启用 DNA 结合活性和细胞骨架蛋白结合活性。参与微管束形成；神经元投射形态发生；和染色质分解的调节。位于多种细胞成分中，包括微管细胞骨架；核腔;和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and cytoskeletal protein binding activity. Involved in microtubule bundle formation; neuron projection morphogenesis; and regulation of chromatin disassembly. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MAP1S 基因产物(2)

mRNA	Protein	Name
NM_001308363.2	NP_001295292.1	microtubule-associated protein 1S isoform 2
NM_018174.6	NP_060644.4	microtubule-associated protein 1S isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	15907802	GOA
NOT enables DNA nuclease activity	IDA IDA: 通过直接分析推断	15907802	GOA
NOT enables actin filament binding	IDA IDA: 通过直接分析推断	12762840	GOA
enables actin filament binding	IDA IDA: 通过直接分析推断	15528209	GOA
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	12762840	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	15528209	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12762840	GOA
enables tubulin binding	IDA IDA: 通过直接分析推断	15528209	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in metaphase chromosome alignment	IMP IMP: 通过突变表型推断	17234756	GOA
involved in microtubule anchoring at centrosome	IMP IMP: 通过突变表型推断	17234756	GOA
involved in microtubule bundle formation	IMP IMP: 通过突变表型推断	15528209	GOA
involved in mitotic spindle organization	IMP IMP: 通过突变表型推断	17234756	GOA
involved in neuron projection morphogenesis	IEP IEP: 通过表达模式推断	15528209	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell projection	IDA IDA: 通过直接分析推断	17658481	GOA
located in centrosome	IDA IDA: 通过直接分析推断	17234756	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12762840	GOA
located in microtubule	IDA IDA: 通过直接分析推断	15528209	GOA
located in microtubule organizing center	IDA IDA: 通过直接分析推断	17234756	GOA
located in mitotic spindle microtubule	IDA IDA: 通过直接分析推断	17234756	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12762840	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12762840	GOA
located in spindle	IDA IDA: 通过直接分析推断	18445686	GOA
located in synapse	IDA IDA: 通过直接分析推断	17658481	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

microtubule-associated protein 1S

BPY2-interacting protein 1

MAP1S 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAP1S	Q66K74	BPY2C	Homo sapiens	O14599	Y2H Pooling	14627543
种属内	MAP1S	Q66K74	BPY2C	Homo sapiens	O14599	Anti Tag CoIP	14627543
种属内	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	IF	19027008
种属内	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	Pull Down	19027008
种属内	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	Y2H	19027008

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteogenesis Imperfecta, Type Xviii

OI18	Osteogenesis Imperfecta Type 18
Osteogenesis Imperfecta, Type 18	Osteogenesis Imperfecta 18

Osteogenesis Imperfecta, Type Viii

Osteogenesis Imperfecta Type 8	OI8
Osteogenesis Imperfecta Type Viii	Oi Type Viii
Oi, Type Viii	Osteogenesis Imperfecta 8
Oi-Viii

Giant Axonal Neuropathy 1, Autosomal Recessive

Giant Axonal Neuropathy	Giant Axonal Neuropathy 1
Gan	GAN1
Giant Axonal Neuropathy-1	Neuropathy, Giant Axonal
Giant Axonal Disease	Neuropathy, Axonal, Giant, Type 1

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08031	MAP1S Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MAP1S	MGD	MGI:2443304
Rattus norvegicus	MAP1S	RGD	RGD:1308266
Bos taurus	MAP1S	VGNC	VGNC:31181
Canis familiaris	MAP1S	VGNC	VGNC:42958
Macaca mulatta	MAP1S	VGNC	VGNC:74294

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAP1S - microtubule associated protein 1S Gene

关于 MAP1S

功能概要

MAP1S 基因产物(2)

MAP1S 蛋白互作信息

关联疾病

直系同源

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MAP1S - microtubule associated protein 1S Gene

关于 MAP1S

功能概要

MAP1S 基因产物(2)

MAP1S 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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