2. Gene
  3. PPP2R3A - protein phosphatase 2 regulatory subunit B''alpha Gene

PPP2R3A - protein phosphatase 2 regulatory subunit B''alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 2 调节亚基 B''alpha

种属: Homo sapiens

同用名: PR72; PR130; PPP2R3

基因 ID: 5523 | 基因类型: protein coding

关于 PPP2R3A

Cytogenetic location: 3q22.2-q22.3 Genomic coordinates (GRCh38): 3:135,965,728-136,147,894 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues.

功能概要

该基因编码蛋白磷酸酶 2 的调节亚基之一。蛋白磷酸酶 2 (以前称为 2A 型) 是四种主要的 Ser/Thr 磷酸酶之一，与细胞生长和分裂的负调控有关。蛋白磷酸酶 2 全酶是由结构亚基 A、催化亚基 C 和调节亚基 B 组成的异源三聚体蛋白。调节亚基由一组不同的基因编码，这些基因被分为 B/PR55、B'/PR61 和 B''/PR72 家族。这些不同的调节亚基赋予全酶不同的酶特异性和细胞内定位。该基因的产物属于 B''家族。 B''家族进一步分为亚科。该基因的产物属于调节亚基 B''的α亚家族。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 6 月]

This gene encodes one of the regulatory subunits of the protein Phosphatase 2. Protein Phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

PPP2R3A 基因产物(3)

mRNA Protein Name
NM_001190447.2 NP_001177376.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3
NM_002718.5 NP_002709.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1
NM_181897.3 NP_871626.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9847399 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
15687260 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in eye photoreceptor cell differentiation IGI
IGI: 通过遗传相互作用推断
15687260 GOA
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
15687260 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
16567647 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
15687260 GOA
involved in regulation of cell migration involved in somitogenic axis elongation IGI
IGI: 通过遗传相互作用推断
15687260 GOA
involved in somatic muscle development IGI
IGI: 通过遗传相互作用推断
15687260 GOA
involved in somitogenesis IGI
IGI: 通过遗传相互作用推断
15687260 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein phosphatase type 2A complex IDA
IDA: 通过直接分析推断
15687260 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP2R3A 蛋白结构

EF-hand_7

EF-hand_7: EF-hand domain pair (907 - 1001)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1150 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

PR130/B''alpha1 subunit

关联疾病

疾病名称 别名
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2

CPVT2

Vtsip

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Ventricular Tachycardia, Stress-Induced Polymorphic

Cvpt2

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

CPVT1

Ventricular Tachycardia, Stress-Induced Polymorphic

Vtsip

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Cvpt1

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Ventricular Tachycardia Catecholaminergic Polymorphic 1

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation

Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11015 PPP2R3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPP2R3A MGD MGI:2442104
Felis catus PPP2R3A VGNC VGNC:69014
Rattus norvegicus PPP2R3A RGD RGD:1306958
Macaca mulatta PPP2R3A VGNC VGNC:76378
Bos taurus PPP2R3A VGNC VGNC:33258
Canis familiaris PPP2R3A VGNC VGNC:44911
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