2. Gene
  3. UBE2W - ubiquitin conjugating enzyme E2 W Gene

UBE2W - ubiquitin conjugating enzyme E2 W Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 W

种属: Homo sapiens

同用名: UBC16; UBC-16

基因 ID: 55284 | 基因类型: protein coding

关于 UBE2W

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,780,096-73,878,862 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.9) and 25 other tissues.

功能概要

该基因编码核定位的泛素结合酶 (E2) ，与泛素激活 (E1) 和连接 (E3) 酶一起协调向现有蛋白质添加泛素部分。编码的蛋白质促进范可尼贫血互补组蛋白的泛素化，可能在 DNA 损伤的修复中起重要作用。该基因在 1 号染色体上有一个假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a nuclear-localized ubiquitin-conjugating Enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) Enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UBE2W 基因产物(3)

mRNA Protein Name
NM_001001481.4 NP_001001481.3 ubiquitin-conjugating enzyme E2 W isoform 1
NM_001271015.3 NP_001257944.2 ubiquitin-conjugating enzyme E2 W isoform 3
NM_018299.6 NP_060769.5 ubiquitin-conjugating enzyme E2 W isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19549727 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
23509263 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
19111657 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
19111657 GOA
enables ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
21229326 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
35893676 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35927303 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
35927303 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein monoubiquitination IDA
IDA: 通过直接分析推断
19111657 GOA
involved in protein monoubiquitination IMP
IMP: 通过突变表型推断
21229326 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2W 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (7 - 141)

  • 0
  • 100
  • 151 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 W

E2 ubiquitin-conjugating enzyme W

UBE2W 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2W Q96B02 PSTPIP1 Homo sapiens O43586
Validated Y2H
25416956
种属内
UBE2W Q96B02 PSTPIP1 Homo sapiens O43586
Y2H Array
25416956
种属内
UBE2W Q96B02 PSTPIP1 Homo sapiens O43586
Y2H
21516116
种属内
UBE2W Q96B02 MARCHF5 Homo sapiens Q9NX47
Y2H Array
19549727
种属内
UBE2W Q96B02 MARCHF5 Homo sapiens Q9NX47
Y2H Array
31515488
种属内
UBE2W Q96B02 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
25416956
种属内
UBE2W Q96B02 MARCHF5 Homo sapiens Q9NX47
Y2H Array
25416956
种属内
UBE2W Q96B02 RNF5 Homo sapiens Q99942
Validated Y2H
25416956
种属内
UBE2W Q96B02 RNF5 Homo sapiens Q99942
Y2H Array
25416956
种属内
UBE2W Q96B02 CCT5 Homo sapiens P48643
Validated Y2H
32814053
种属内
UBE2W Q96B02 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
种属内
UBE2W Q96B02 CCT5 Homo sapiens P48643
Y2H Array
32814053
种属内
UBE2W Q96B02 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2W 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77272 UBE2W Protein, Human (His) Q96B02-1 (M1-C151) ≥95%

关联疾病

疾病名称 别名
Brachydactyly, Type E2

Brachydactyly Type E2

BDE2

Brachydactyly E2
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15366 UBE2W Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UBE2W RGD RGD:6503620
Macaca mulatta UBE2W VGNC VGNC:99479
Mus musculus UBE2W MGD MGI:1914049
Others UBE2W NCBI
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