2. Gene
  3. PPP3CB - protein phosphatase 3 catalytic subunit beta Gene

PPP3CB - protein phosphatase 3 catalytic subunit beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 3 催化亚基 β

种属: Homo sapiens

同用名: CNA2; CALNB; CALNA2; PP2Bbeta

基因 ID: 5532 | 基因类型: protein coding

关于 PPP3CB

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,436,433-73,496,024 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues.

功能概要

启用多种功能，包括钙调蛋白结合活性；钙调蛋白依赖性蛋白磷酸酶活性；和蛋白磷酸酶 2B 结合活性。参与钙调神经磷酸酶-NFAT 信号级联； RNA 聚合酶 II 对转录的正调控；和蛋白质去磷酸化。位于细胞质中。神经钙蛋白复合物的一部分。与主动脉瓣狭窄有关。局灶节段性肾小球硬化和精神分裂症的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Calmodulin binding activity; calmodulin-dependent protein Phosphatase activity; and protein Phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of Calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PPP3CB 基因产物(5)

mRNA Protein Name
NM_001142353.3 NP_001135825.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a
NM_001142354.3 NP_001135826.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c
NM_001289968.2 NP_001276897.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform d
NM_001289969.2 NP_001276898.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform e
NM_021132.4 NP_066955.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
8524402 GOA
enables calmodulin binding IDA
IDA: 通过直接分析推断
2556704 GOA
enables calmodulin-dependent protein phosphatase activity IDA
IDA: 通过直接分析推断
19154138 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
11005320 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21903422 GOA
enables protein dimerization activity IPI
IPI: 通过物理相互作用推断
11005320 GOA
enables protein phosphatase 2B binding IDA
IDA: 通过直接分析推断
2556704 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcineurin-NFAT signaling cascade IDA
IDA: 通过直接分析推断
19154138 GOA
involved in calcineurin-mediated signaling IMP
IMP: 通过突变表型推断
11005320 GOA
involved in positive regulation of lysosome organization IDA
IDA: 通过直接分析推断
25720963 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
25720963 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22688515 GOA
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
19154138 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcineurin complex IDA
IDA: 通过直接分析推断
8524402 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
19154138 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP3CB 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (93 - 293)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 524 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

CAM-PRP catalytic subunit

关联疾病

疾病名称 别名
Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11024 PPP3CB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PPP3CB VGNC VGNC:82211
Mus musculus PPP3CB MGD MGI:107163
Felis catus PPP3CB VGNC VGNC:69020
Canis familiaris PPP3CB VGNC VGNC:44919
Rattus norvegicus PPP3CB RGD RGD:3383
Bos taurus PPP3CB VGNC VGNC:33266
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