2. Gene
  3. AGPAT5 - 1-acylglycerol-3-phosphate O-acyltransferase 5 Gene

AGPAT5 - 1-acylglycerol-3-phosphate O-acyltransferase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-酰基甘油-3-磷酸 O-酰基转移酶 5

种属: Homo sapiens

同用名: LPAATE; LPLAT5; 1AGPAT5

基因 ID: 55326 | 基因类型: protein coding

关于 AGPAT5

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,708,642-6,761,503 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 211 orthologues and 4 paralogues. Broad expression in testis (RPKM 16.0), brain (RPKM 13.8) and 23 other tissues.

功能概要

该基因编码 1-acylglycerol-3-phosphate O-acyltransferase 家族的成员。这种完整的膜蛋白将溶血磷脂酸转化为磷脂酸，这是磷脂从头生物合成的第二步。该基因的假基因存在于 Y 染色体上。[RefSeq 提供，2014 年 8 月]

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]

AGPAT5 基因产物(1)

mRNA Protein Name
NM_018361.5 NP_060831.2 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: 通过直接分析推断
21173190 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
21173190 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
21173190 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
21173190 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGPAT5 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (82 - 232)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1-AGP acyltransferase 5

AGPAT5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AGPAT5 Q9NUQ2 CYB561A3 Homo sapiens Q8NBI2
Y2H Array
32296183
种属内
AGPAT5 Q9NUQ2 CYB561A3 Homo sapiens Q8NBI2
Y2H Prey Pooling
32296183
种属内
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
种属内
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
种属内
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
种属内
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
AGPAT5 Q9NUQ2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
AGPAT5 Q9NUQ2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fetal Akinesia Deformation Sequence 4

FADS4

Fetal Akinesia Deformation Sequence Syndrome 4

Akinesia, Fetal, Deformation Sequence, Type 4
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00460 AGPAT5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AGPAT5 RGD RGD:1306405
Canis familiaris AGPAT5 VGNC VGNC:49767
Bos taurus AGPAT5 VGNC VGNC:25738
Felis catus AGPAT5 VGNC VGNC:59688
Macaca mulatta AGPAT5 VGNC VGNC:69655
Mus musculus AGPAT5 MGD MGI:1196345
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