PRCC - proline rich mitotic checkpoint control factor Gene

中文名称：富脯氨酸的有丝分裂检查点控制因子

种属: Homo sapiens

同用名: TPRC; RCCP1

基因 ID: 5546 | 基因类型: protein coding

关于 PRCC

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,767,535-156,800,815 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and is associated with 68 phenotypes. Ubiquitous expression in brain (RPKM 14.8), spleen (RPKM 14.1) and 25 other tissues.

功能概要

该基因编码的蛋白质可能在 pre-mRNA 剪接中发挥作用。导致该基因与 TFE3 (GeneID 7030) 融合的染色体易位 (X;1) (p11;q21) 与乳头状肾细胞癌相关。 PRCC-TFE3 融合蛋白在受影响的癌中表达，并且可能与改变的基因反式激活有关。这种融合蛋白也与细胞周期的破坏有关。[RefSeq 提供，2010 年 8 月]

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

PRCC 基因产物(1)

mRNA	Protein	Name
NM_005973.5	NP_005964.3	proline-rich protein PRCC

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11717438	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	11717438	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	11717438	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRCC 蛋白结构

PRCC

0
100
200
300
400
491 a.a.

蛋白主名

其他名称

proline-rich protein PRCC

PRCC, proline rich mitotic checkpoint control factor

PRCC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRCC	Q92733	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	26871637
种属内	PRCC	Q92733	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	26871637
种属内	PRCC	Q92733	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	26871637

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Renal Cell Carcinoma, Xp11-Associated

RCCX1	Mit Family Translocation Renal Cell Carcinoma
Renal Cell Carcinoma, Papillary, 1	Carcinoma Associated With Mitf/Tfe Translocation
Translocation Renal Cell Carcinoma	Renal Cell Carcinoma Xp11-Associated
Renal Cell Carcinoma Papillary 1	Carcinoma, Renal Cell, Xp11-Associated

Late Yaws

Yaws Gummata And Ulcers	Gummata And Ulcers Due To Yaws
Gummata Of Yaws	Gummatous Frambeside
Multiple Papillomata Due To Yaws And Wet Crab Yaws	Nodular Late Yaws
Ulcers Of Yaws

Epithelial Predominant Wilms' Tumor

Epithelial Predominant Kidney Adenosarcoma	Epithelial Predominant Renal Wilms Tumor
Epithelial Predominant Renal Wilms Tumour	Epithelial Predominant Wilms' Tumour

Childhood Kidney Cell Carcinoma

Pediatric Renal Cell Carcinoma

Childhood Renal Cell Carcinoma

Metanephric Adenoma

Renal Adenoma

Renal Cell Adenoma

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Nephrogenic Adenofibroma

Metanephric Adenofibroma

Collecting Duct Carcinoma

Kidney Medullary Carcinoma	Renal Medullary Carcinoma
Bdc	Bellini Carcinoma
Bellini Duct Carcinoma	Cdc
Collecting Duct Carcinoma Of The Kidney	Renal Cell Adenocarcinoma
Carcinoma Of Renal Collecting Duct	Renal Carcinoma, Collecting Duct Type
Renal Cell Carcinoma	Bellini'S Duct Carcinoma
Renal Collecting Duct Carcinoma	Adenocarcinoma Of Kidney

Perivascular Epithelioid Cell Tumor

Pecoma	Perivascular Epithelioid Cell Neoplasms
Neoplasm With Perivascular Epithelioid Cell Differentiation

Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency	4-Hppd Deficiency
4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency	HWKS
HAWK

Bejel

Njovera	Dichuchwa
Nonvenereal Endemic Syphilis	Endemic Syphilis
Frenga	Nonvenereal Syphilis
Treponemal Infections	Non-Venereal Endemic Syphilis
Siti	Skerljevo
Belesh

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Kidney Benign Neoplasm

Renal And Ureteral Tumor

Benign Kidney Neoplasm

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11056	PRCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PRCC	RGD	RGD:1309037
Felis catus	PRCC	VGNC	VGNC:69031
Canis familiaris	PRCC	VGNC	VGNC:56084
Macaca mulatta	PRCC	VGNC	VGNC:100046
Mus musculus	PRCC	MGD	MGI:2137738
Bos taurus	PRCC	VGNC	VGNC:56085

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRCC - proline rich mitotic checkpoint control factor Gene

关于 PRCC

功能概要

PRCC 基因产物(1)

PRCC 蛋白结构

PRCC 蛋白互作信息

关联疾病

直系同源

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PRCC - proline rich mitotic checkpoint control factor Gene

关于 PRCC

功能概要

PRCC 基因产物(1)

PRCC 蛋白结构

PRCC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

S

T

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