2. Gene
  3. DNAJA4 - DnaJ heat shock protein family (Hsp40) member A4 Gene

DNAJA4 - DnaJ heat shock protein family (Hsp40) member A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 A4

种属: Homo sapiens

同用名: MST104; MSTP104; PRO1472

基因 ID: 55466 | 基因类型: protein coding

关于 DNAJA4

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues.

功能概要

启用分子伴侣结合活性和未折叠蛋白结合活性。参与多个过程，包括内皮细胞迁移的负调节；包涵体组装的负调控；和蛋白质重折叠。位于胞质溶胶和膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]

DNAJA4 基因产物(8)

mRNA Protein Name
NM_001130182.2 NP_001123654.1 dnaJ homolog subfamily A member 4 isoform 2
NM_001130183.2 NP_001123655.1 dnaJ homolog subfamily A member 4 isoform 3
NM_001387384.1 NP_001374313.1 dnaJ homolog subfamily A member 4 isoform 4
NM_001387385.1 NP_001374314.1 dnaJ homolog subfamily A member 4 isoform 2
NM_001387386.1 NP_001374315.1 dnaJ homolog subfamily A member 4 isoform 5
NM_001387387.1 NP_001374316.1 dnaJ homolog subfamily A member 4 isoform 6
NM_001387388.1 NP_001374317.1 dnaJ homolog subfamily A member 4 isoform 2
NM_018602.4 NP_061072.3 dnaJ homolog subfamily A member 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25036637 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
21231916 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
21231916 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
23142051 GOA
involved in negative regulation of inclusion body assembly IDA
IDA: 通过直接分析推断
21231916 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
23142051 GOA
involved in protein refolding IDA
IDA: 通过直接分析推断
21231916 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
21231916 GOA
located in membrane IDA
IDA: 通过直接分析推断
21231916 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNAJA4 蛋白结构

DnaJ

DnaJ: DnaJ domain (7 - 65)

DnaJ_CXXCXGXG

DnaJ_CXXCXGXG: DnaJ central domain (135 - 201)

DnaJ_C

DnaJ_C: DnaJ C terminal domain (258 - 332)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

dnaJ homolog subfamily A member 4

DnaJ (Hsp40) homolog, subfamily A, member 4

DNAJA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DNAJA4 Q8WW22 DNAJA2 Homo sapiens O60884
Anti Tag CoIP
25036637
种属内
DNAJA4 Q8WW22 DNAJA2 Homo sapiens O60884
Lumier
25036637
种属内
DNAJA4 Q8WW22 ENDOG Homo sapiens Q14249
Anti Tag CoIP
25036637
种属内
DNAJA4 Q8WW22 ENDOG Homo sapiens Q14249
Lumier
25036637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Plantar Wart

Verruca Plantaris

Verrucae On Sole Of Foot

Mosaic Plantar Warts
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03860 DNAJA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DNAJA4 RGD RGD:1310035
Macaca mulatta DNAJA4 VGNC VGNC:84334
Bos taurus DNAJA4 VGNC VGNC:53935
Mus musculus DNAJA4 MGD MGI:1927638
Felis catus DNAJA4 VGNC VGNC:80985
Canis familiaris DNAJA4 VGNC VGNC:59071
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