2. Gene
  3. KIF27 - kinesin family member 27 Gene

KIF27 - kinesin family member 27 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白家族成员 27

种属: Homo sapiens

基因 ID: 55582 | 基因类型: protein coding

关于 KIF27

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,834,099-83,921,432 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 41 paralogues. Broad expression in testis (RPKM 7.5), thyroid (RPKM 3.1) and 21 other tissues.

功能概要

该基因是哺乳动物驱动蛋白家族的 KIF27 (驱动蛋白 4) 亚家族的成员。该基因是果蝇 Cos2 基因的直系同源基因，在 Hedgehog 信号通路中起着重要作用。编码的蛋白质包含一个 N 末端运动结构域，其中包括核苷酸结合和微管相互作用区域，一个包含预测的卷曲螺旋基序的茎结构域和一个 C 末端尾部结构域。已观察到该基因的可变剪接转录物变体。与该基因相关的假基因位于 9 号染色体上。[RefSeq 提供，2012 年 12 月]

This gene is a member of the KIF27 (Kinesin 4) sub-family of the mammalian Kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

KIF27 基因产物(6)

mRNA Protein Name
NM_001271927.3 NP_001258856.1 kinesin-like protein KIF27 isoform B
NM_001271928.3 NP_001258857.1 kinesin-like protein KIF27 isoform C
NM_001354069.2 NP_001340998.1 kinesin-like protein KIF27 isoform D
NM_001354070.2 NP_001340999.1 kinesin-like protein KIF27 isoform E
NM_001354071.2 NP_001341000.1 kinesin-like protein KIF27 isoform F
NM_017576.4 NP_060046.1 kinesin-like protein KIF27 isoform A
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF27 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (11 - 341)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1401 a.a.
蛋白主名 其他名称

kinesin-like protein KIF27

KIF27 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KIF27 Q86VH2 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
种属内
KIF27 Q86VH2 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
种属内
KIF27 Q86VH2 MAGEA3 Homo sapiens P43357
Y2H Prey Pooling
32296183
种属内
KIF27 Q86VH2 MAGEA3 Homo sapiens P43357
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma
Acrocallosal Syndrome

ACLS

Schinzel Acrocallosal Syndrome

Joubert Syndrome 12

Schinzel Syndrome 1

Acrocallosal Syndrome, Schinzel Type

Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum

Acs

Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly

Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum

JBTS12

Acrocallosal Syndrome

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Megabladder, Congenital

MGBL

Congenital Megabladder
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07281 KIF27 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus KIF27 VGNC VGNC:30598
Macaca mulatta KIF27 VGNC VGNC:73851
Rattus norvegicus KIF27 RGD RGD:621071
Mus musculus KIF27 MGD MGI:1922300
Canis familiaris KIF27 VGNC VGNC:42401
Felis catus KIF27 VGNC VGNC:63117
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