PRR5 - proline rich 5 Gene

中文名称：富脯氨酸 5

种属: Homo sapiens

同用名: PP610; PROTOR1; PROTOR-1; FLJ20185k

关于 PRR5

功能概要

该基因编码的蛋白质具有富含脯氨酸的结构域。该基因位于 22 号染色体的一个区域，据报道该区域含有一个可能参与乳腺和结直肠肿瘤发生的抑癌基因。该蛋白是雷帕霉素复合物 2 (mTORC2) 的哺乳动物靶标的组成部分，它调节血小板衍生生长因子 (PDGF) 受体 β 表达和 PDGF 向 Akt 和 S6K1 的信号传导。可变剪接和替代启动子的使用导致转录本编码不同的亚型。从该基因到下游 Rho GTP 酶激活蛋白 8 (ARHGAP8) 基因的通读转录本也存在，这导致最初将 PRR5 和 ARHGAP8 描述为单个基因。[RefSeq 提供，2010 年 11 月]

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]