2. Gene
  3. SLC30A6 - solute carrier family 30 member 6 Gene

SLC30A6 - solute carrier family 30 member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 30 成员 6

种属: Homo sapiens

同用名: ZNT6; MST103; MSTP103

基因 ID: 55676 | 基因类型: protein coding

关于 SLC30A6

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,165,864-32,224,379 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 4.9), urinary bladder (RPKM 4.1) and 25 other tissues.

功能概要

该基因编码作为锌转运蛋白的蛋白质家族的成员。这种蛋白质可以调节高尔基体和囊泡中锌的亚细胞水平。该基因的表达在阿尔茨海默病脑斑块中发生了改变。[RefSeq 提供，2016 年 8 月]

This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

SLC30A6 基因产物(8)

mRNA Protein Name
NM_001193513.3 NP_001180442.1 zinc transporter 6 isoform 1
NM_001193514.3 NP_001180443.1 zinc transporter 6 isoform 3
NM_001193515.3 NP_001180444.1 zinc transporter 6 isoform 4
NM_001330476.2 NP_001317405.1 zinc transporter 6 isoform 5
NM_001330477.2 NP_001317406.1 zinc transporter 6 isoform 6
NM_001330478.2 NP_001317407.1 zinc transporter 6 isoform 6
NM_001330479.2 NP_001317408.1 zinc transporter 6 isoform 7
NM_017964.5 NP_060434.2 zinc transporter 6 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15994300 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
15994300 GOA
NOT enables zinc:proton antiporter activity IDA
IDA: 通过直接分析推断
19366695 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of zinc ion transport IDA
IDA: 通过直接分析推断
19366695 GOA
involved in zinc ion import into Golgi lumen IDA
IDA: 通过直接分析推断
15994300 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17349999 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
19366695 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC30A6 蛋白结构

Cation_efflux

Cation_efflux: Cation efflux family (35 - 331)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

zinc transporter 6

solute carrier family 30 (zinc transporter), member 6

SLC30A6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC30A6 Q6NXT4 SLC30A5 Homo sapiens Q8TAD4
Anti Tag CoIP
19759014
种属内
SLC30A6 Q6NXT4 SLC30A5 Homo sapiens Q8TAD4
IF
19759014
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

HMNDYT1

Hmdpc

Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia 2

HMNDYT2

Dystonia-Parkinsonism-Hypermanganesemia Syndrome

Hypermanganesemia With Dystonia, Type 2
Spastic Paraplegia 4, Autosomal Dominant

SPG4

Hereditary Spastic Paraplegia 4

Fsp2

Autosomal Dominant Spastic Paraplegia Type 4

Familial Spastic Paraplegia, Autosomal Dominant, 2

Autosomal Dominant Spastic Paraplegia 4

Familial Spastic Paraplegia Autosomal Dominant 2

Paraplegia, Spastic, Autosomal Dominant, Type 4
Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt
Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13184 SLC30A6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC30A6 MGD MGI:2386741
Macaca mulatta SLC30A6 VGNC VGNC:77513
Rattus norvegicus SLC30A6 RGD RGD:1309250
Felis catus SLC30A6 VGNC VGNC:65312
Bos taurus SLC30A6 VGNC VGNC:34810
Canis familiaris SLC30A6 VGNC VGNC:46351
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