2. Gene
  3. MREG - melanoregulin Gene

MREG - melanoregulin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：黑色素调节素

种属: Homo sapiens

同用名: DSU; WDT2

基因 ID: 55686 | 基因类型: protein coding

关于 MREG

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:215,939,308-216,034,096 (from NCBI)

This gene has 5 transcripts (splice variants) and 118 orthologues. Broad expression in esophagus (RPKM 7.4), skin (RPKM 5.3) and 22 other tissues.

功能概要

预测可启用磷脂酰肌醇结合活性。预计参与黑素细胞分化；黑素体运输；和吞噬体成熟。预计在发育色素沉着的上游或内部起作用。预测位于晚期核内体膜和黑素体膜。预测为细胞器膜的固有成分。预计是含蛋白质复合物的一部分。预计在黑素体中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Apr 2022]

MREG 基因产物(4)

mRNA Protein Name
NM_001372188.1 NP_001359117.1 melanoregulin isoform 1
NM_001372189.1 NP_001359118.1 melanoregulin isoform 3
NM_001372190.1 NP_001359119.1 melanoregulin isoform 3
NM_018000.3 NP_060470.2 melanoregulin isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

melanoregulin

dilute suppressor protein homolog

MREG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MREG Q8N565 EIF1AD Homo sapiens Q8N9N8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neuroaspergillosis
Brugada Syndrome 2

BRGDA2

Brugada Syndrome, Type 2
Jaw Cancer

Jaw Neoplasms

Jaw Neoplasm

Neoplasm Of Jaw

Cancer Of Jaw
Reflex Epilepsy

Epilepsy, Reflex

Epilepsy, Sensory-Induced

Epilepsy Reflex
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08644 MREG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MREG VGNC VGNC:43362
Rattus norvegicus MREG RGD RGD:1562333
Macaca mulatta MREG VGNC VGNC:74826
Bos taurus MREG VGNC VGNC:31601
Felis catus MREG VGNC VGNC:107583
Mus musculus MREG MGD MGI:2151839
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