2. Gene
  3. ASF1B - anti-silencing function 1B histone chaperone Gene

ASF1B - anti-silencing function 1B histone chaperone Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抗沉默功能 1B 组蛋白伴侣

种属: Homo sapiens

同用名: CIA-II

基因 ID: 55723 | 基因类型: protein coding

关于 ASF1B

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,119,512-14,136,589 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 265 orthologues and 1 paralogue. Biased expression in testis (RPKM 18.2), lymph node (RPKM 12.4) and 13 other tissues.

功能概要

该基因编码组蛋白伴侣蛋白 H3/H4 家族的成员，类似于酵母中的抗沉默功能 1 基因。所编码的蛋白质是细胞周期调节激酶的杂乱样激酶家族的底物，并且可能通过确保在核小体组装位点持续供应组蛋白而在调节染色质的核小体结构中发挥关键作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]

ASF1B 基因产物(1)

mRNA Protein Name
NM_018154.3 NP_060624.1 histone chaperone ASF1B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone chaperone activity IDA
IDA: 通过直接分析推断
12842904 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16980972 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
14718166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
14718166 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
14718166 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASF1B 蛋白结构

ASF1_hist_chap

ASF1_hist_chap: ASF1 like histone chaperone (1 - 154)

  • 0
  • 100
  • 202 a.a.
蛋白主名 其他名称

histone chaperone ASF1B

ASF1 anti-silencing function 1 homolog B

重组 ASF1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76157 ASF1B Protein, Human (sf9, His) Q9NVP2 (M1-I202) ≥95%

关联疾病

疾病名称 别名
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I

Cda I

CDAN1A

Congenital Dyserythropoietic Anemia Type 1

Congenital Dyserythropoietic Anemia Type Ia

Congenital Dyserythropoietic Anemia, Type I

Anemia, Congenital Dyserythropoietic, Type I

Cda Type 1

Cda Type I

Cda Ia

Dyserythropoietic Anemia, Congenital Type 1

Anemia, Congenital Dyserythropoietic, Type 1a

Dyserythropoietic Anemia, Congenital, Type Ia

Cda, Type Ia

Congenital Dyserythropoietic Anaemia Type 1

Congenital Dyserythropoietic Anaemia Type I

Anemia, Dyserythropoietic, Congenital Type 1

Type I Congenital Dyserythropoietic Anemia

Anemia, Congenital Dyserythropoietic, 1a

Anemia, Dyserythropoietic, Congenital, Type Ia
Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3

Cataract 34 Multiple Types

CTRCT34

Catc3

Cataract 34, Multiple Types, With Or Without Microcornea

Autosomal Recessive Congenital Cataract 3

Cataract 34 Multiple Types With Or Without Microcornea

Cataract, Multiple Types, Type 34
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01084 ASF1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ASF1B MGD MGI:1914179
Macaca mulatta ASF1B VGNC VGNC:69872
Felis catus ASF1B VGNC VGNC:59969
Bos taurus ASF1B VGNC VGNC:50605
Rattus norvegicus ASF1B RGD RGD:1304918
Others ASF1B NCBI
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