2. Gene
  3. FGD6 - FYVE, RhoGEF and PH domain containing 6 Gene

FGD6 - FYVE, RhoGEF and PH domain containing 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 FYVE、RhoGEF 和 PH 域 6

种属: Homo sapiens

同用名: ZFYVE24

基因 ID: 55785 | 基因类型: protein coding

关于 FGD6

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,076,749-95,217,467 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 3.9), gall bladder (RPKM 3.5) and 25 other tissues.

功能概要

预测可实现胍基核苷酸交换因子活性和小 GTP 酶结合活性。预计将参与多个过程，包括丝状足的组装；调节 GTPase 活性；和细胞形状的调节。预测位于高尔基体；片状足；和荷叶边。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FGD6 基因产物(1)

mRNA Protein Name
NM_018351.4 NP_060821.3 FYVE, RhoGEF and PH domain-containing protein 6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FGD6 蛋白结构

RhoGEF

RhoGEF: RhoGEF domain (875 - 1059)

PH

PH: PH domain (1092 - 1182)

FYVE

FYVE: FYVE zinc finger (1218 - 1281)

PH

PH: PH domain (1336 - 1426)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1430 a.a.
蛋白主名 其他名称

FYVE, RhoGEF and PH domain-containing protein 6

zinc finger FYVE domain-containing protein 24

FGD6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FGD6 Q6ZV73 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04885 FGD6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FGD6 VGNC VGNC:72548
Bos taurus FGD6 VGNC VGNC:28969
Felis catus FGD6 VGNC VGNC:62244
Mus musculus FGD6 MGD MGI:1261419
Canis familiaris FGD6 VGNC VGNC:40838
Rattus norvegicus FGD6 RGD RGD:1565609
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