1. Gene
  2. PAG1 - phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Gene

PAG1 - phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Gene

中文名称:磷蛋白膜锚与糖脂微区 1

种属: Homo sapiens

同用名: CBP; PAG

基因 ID: 55824 | 基因类型: protein coding

关于 PAG1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:80,967,810-81,112,068 (from NCBI)

This gene has 4 transcripts (splice variants) and 193 orthologues. Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 III 型跨膜衔接蛋白,可与酪氨酸激酶 csk 蛋白结合。它被认为参与了 T 细胞活化的调节。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

PAG1 基因产物(1)

mRNA Protein Name
NM_018440.4 NP_060910.3 phosphoprotein associated with glycosphingolipid-enriched microdomains 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IDA
IDA: 通过直接分析推断
10790433 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10790433 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10790433 GOA
involved in regulation of T cell activation IDA
IDA: 通过直接分析推断
10790433 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane raft IDA
IDA: 通过直接分析推断
10790433 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10790433 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PAG1 蛋白结构

PAG

PAG: Phosphoprotein associated with glycosphingolipid-enriched (1 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Csk-binding protein

PAG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PAG1 Q9NWQ8 CSK Homo sapiens P41240 18070987
种属内
PAG1 Q9NWQ8 RACK1 Homo sapiens P63244 23866081
种属内
PAG1 Q9NWQ8 FYN Homo sapiens P06241 18056706
种属内
PAG1 Q9NWQ8 FYN Homo sapiens P06241 18056706
种属内
PAG1 Q9NWQ8 LYN Homo sapiens P07948 18070987
种属内
PAG1 Q9NWQ8 LYN Homo sapiens P07948 23866081
种属间: 跨种属相互作用 种属内: 同种属相互作用

PAG1 抗体

目录号 产品名 应用 反应物种
HY-P82223 PAG1 Antibody (YA1968) WB, IHC-P, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome

Del(8)(Q21.11)

Deletion 8q21.11

Monosomy 8q21.11

B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy

B-All With Hypodiploidy

Hypodiploid All

Peters-Plus Syndrome

Krause-Kivlin Syndrome

Peters Plus Syndrome

Peters Anomaly

Irido-Corneo-Trabecular Dysgenesis

PTRPLS

Peters Anomaly With Short-Limb Dwarfism

Peters Anomaly-Short Limb Dwarfism Syndrome

Peters Anomaly With Short Limb Dwarfism

Peters Congenital Glaucoma

Krause-Van Schooneveld-Kivlin Syndrome

Peters' Plus Syndrome

Peters'-Plus Syndrome

Anomaly Peters

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PAG1 VGNC VGNC:32553
Felis catus PAG1 VGNC VGNC:64025
Rattus norvegicus PAG1 RGD RGD:620394
Canis familiaris PAG1 VGNC VGNC:44242
Mus musculus PAG1 MGD MGI:2443160
Macaca mulatta PAG1 VGNC VGNC:75698
Others PAG1 NCBI