MAPK13 - mitogen-activated protein kinase 13 Gene

中文名称：丝裂原活化蛋白激酶 13

种属: Homo sapiens

同用名: SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta

关于 MAPK13

功能概要

该基因编码丝裂原活化蛋白 (MAP) 激酶家族的成员。 MAP 激酶作为多种生化信号的整合点，参与多种细胞过程，如增殖、分化、转录调控和发育。编码的蛋白质是一种 p38 MAP 激酶，被促炎细胞因子和细胞应激激活。编码蛋白的底物包括转录因子 ATF2 和微管动力学调节因子 stathmin。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]