2. Gene
  3. MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶激酶 7

种属: Homo sapiens

同用名: MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

基因 ID: 5609 | 基因类型: protein coding

关于 MAP2K7

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,903,877-7,914,478 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种双特异性蛋白激酶，属于 MAP 激酶激酶家族。该激酶特异性激活 MAPK8/JNK1 和 MAPK9/JNK2，并且该激酶本身被 MAP 激酶激酶磷酸化并激活，包括 MAP3K1/MEKK1、MAP3K2/MEKK2、MAP3K3/MEKK5 和 MAP4K2/GCK。该激酶参与介导细胞对促炎细胞因子和环境压力的反应的信号转导。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP2K7 基因产物(3)

mRNA Protein Name
NM_001297555.2 NP_001284484.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001297556.2 NP_001284485.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 2
NM_145185.4 NP_660186.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase kinase activity IDA
IDA: 通过直接分析推断
9535930 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
14615289 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
9535930 GOA
enables molecular function activator activity EXP
EXP: 通过实验结果推断
25737554 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15299019 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
14697235 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
28111074 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
28111074 GOA
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
21531765 GOA
involved in response to UV IDA
IDA: 通过直接分析推断
9535930 GOA
involved in response to heat IDA
IDA: 通过直接分析推断
9535930 GOA
involved in response to osmotic stress IDA
IDA: 通过直接分析推断
9535930 GOA
involved in response to tumor necrosis factor IDA
IDA: 通过直接分析推断
9535930 GOA
involved in stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
9535930 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP2K7 蛋白结构

Pkinase

Pkinase: Protein kinase domain (122 - 380)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
蛋白主名 其他名称

dual specificity mitogen-activated protein kinase kinase 7

JNK-activating kinase 2

MAP2K7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP2K7 O14733 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
MAP2K7 O14733 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
MAP2K7 O14733 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
MAP2K7 O14733 MAP3K7 Homo sapiens O43318
PLA
25241761
种属内
MAP2K7 O14733 GADD45B Homo sapiens O75293
CD
25314077
种属内
MAP2K7 O14733 GADD45B Homo sapiens O75293
Solid Phase Assay
25314077
种属内
MAP2K7 O14733 CFLAR Homo sapiens O15519-1
Anti Tag CoIP
17110930
种属内
MAP2K7 O14733 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
20067578
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25
Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube
Mucocele Of Appendix

Appendicele Mucocele

Appendicular Mucocele

Appendiceal Mucocele
Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-D2415 BODIPY-FL staurosporine / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAP2K7 RGD RGD:1560043
Canis familiaris MAP2K7 VGNC VGNC:42965
Macaca mulatta MAP2K7 VGNC VGNC:81457
Bos taurus MAP2K7 VGNC VGNC:54447
Mus musculus MAP2K7 MGD MGI:1346871
Felis catus MAP2K7 VGNC VGNC:80622
Others MAP2K7 NCBI
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