PSPN - persephin Gene

中文名称：persephin

种属: Homo sapiens

同用名: PSP

基因 ID: 5623 | 基因类型: protein coding

关于 PSPN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,375,148-6,375,933 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues and 3 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码 GDNF (神经胶质细胞系衍生的神经营养因子) 亚家族和 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。编码的前原蛋白经过蛋白水解处理以生成成熟蛋白。这种蛋白质通过 RET 受体酪氨酸激酶和 GPI 相关辅助受体发出信号，并促进神经元群的存活。这种蛋白质可能在细胞死亡、神经系统发育和功能中发挥作用。已在口腔鳞状细胞癌中观察到该基因表达升高。[RefSeq 提供，2016 年 8 月]

This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]

PSPN 基因产物(1)

mRNA	Protein	Name
NM_004158.5	NP_004149.1	persephin preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables growth factor activity	IDA IDA: 通过直接分析推断	11116144	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in glial cell-derived neurotrophic factor receptor signaling pathway	IDA IDA: 通过直接分析推断	11116144	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in extracellular space	IDA IDA: 通过直接分析推断	9491986	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSPN 蛋白结构

TGF_beta

0
100
156 a.a.

蛋白主名

其他名称

persephin

重组 PSPN 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71034	Persephin Protein, Human	O60542 (A61-G156)	≥95%

关联疾病

疾病名称

别名

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b	MEN2B
Wagenmann-Froboese Syndrome	Multiple Endocrine Neoplasia Iib
Mucosal Neuroma Syndrome	Multiple Endocrine Neoplasia, Type 3
Multiple Endocrine Neoplasia, Type 2b	Men Iib
Neuromata, Mucosal, With Endocrine Tumors	Multiple Endocrine Neoplasia, Type Iii, Formerly
Men3, Formerly	Men Type Iib
Men 2b	Multiple Endocrine Neoplasia Type 3
Multiple Neoplasia 2b	Neoplasia, Endocrine, Multiple, Type Iib

Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a	Sipple Syndrome
Multiple Endocrine Neoplasia Type 2	MEN2A
Men2	Ptc Syndrome
Multiple Endocrine Neoplasia, Type 2	Multiple Endocrine Neoplasia Iia
Men 2a	Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia, Type 2a	Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia Ii	Men2 Syndrome
Men-2a Syndrome	Multiple Neoplasia 2a
Multiple Neoplasia Type 2

Megacolon

Dilatation Of Colon

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Medullary Thyroid Cancer
Fmtc	Mtc1
Thyroid Cancer, Medullary	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11342	PSPN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PSPN	MGD	MGI:1201684
Rattus norvegicus	PSPN	RGD	RGD:3432
Bos taurus	PSPN	VGNC	VGNC:52869
Felis catus	PSPN	VGNC	VGNC:102668
Canis familiaris	PSPN	VGNC	VGNC:49950
Others	PSPN	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PSPN - persephin Gene

关于 PSPN

功能概要

PSPN 基因产物(1)

PSPN 蛋白结构

重组 PSPN 蛋白

关联疾病

直系同源

热门区域

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PSPN - persephin Gene

关于 PSPN

功能概要

PSPN 基因产物(1)

PSPN 蛋白结构

重组 PSPN 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z