GKN1 - gastrokine 1 Gene

中文名称：胃泌素 1

种属: Homo sapiens

同用名: FOV; CA11; AMP18; BRICD1; foveolin

基因 ID: 56287 | 基因类型: protein coding

关于 GKN1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,974,636-68,980,976 (from NCBI)

This gene has 3 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 11425.3).

功能概要

与正常胃粘膜相比，发现由该基因编码的蛋白质在人胃癌组织中下调。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is found to be down-regulated in human gastric Cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GKN1 基因产物(1)

mRNA	Protein	Name
NM_019617.4	NP_062563.4	gastrokine-1 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular region	IDA IDA: 通过直接分析推断	15221938	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GKN1 蛋白结构

BRICHOS

0
100
199 a.a.

蛋白主名

其他名称

gastrokine-1

18 kDa antrum mucosa protein

GKN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GKN1	Q9NS71	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
种属内	GKN1	Q9NS71	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
种属内	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
种属内	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
种属内	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	GKN1	Q9NS71	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
种属内	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
种属内	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
种属内	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
种属内	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
种属内	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
种属内	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
种属内	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
种属内	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
种属内	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	GKN1	Q9NS71	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GKN1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76356	Gastrokine 1 Protein, Human (sf9, His)	Q9NS71 (N35-N199)	≥95%

关联疾病

疾病名称

别名

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05461	GKN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	GKN1	VGNC	VGNC:41246
Mus musculus	GKN1	MGD	MGI:1913533
Bos taurus	GKN1	VGNC	VGNC:29388
Felis catus	GKN1	VGNC	VGNC:62570
Rattus norvegicus	GKN1	RGD	RGD:735014
Others	GKN1	NCBI

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