KLK7 - kallikrein related peptidase 7 Gene

中文名称：激肽释放酶相关肽酶 7

种属: Homo sapiens

同用名: hK7; SCCE; PRSS6

基因 ID: 5650 | 基因类型: protein coding

关于 KLK7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,976,468-50,984,064 (from NCBI)

This gene has 6 transcripts (splice variants), 107 orthologues and 12 paralogues. Biased expression in skin (RPKM 68.1) and esophagus (RPKM 25.3).

功能概要

该基因编码丝氨酸蛋白酶激肽释放酶亚家族的成员。这些酶具有多种生理功能，许多激肽释放酶基因是癌症的生物标志物。编码的蛋白质具有胰凝乳蛋白酶样活性，并在脱屑 (表皮最外层脱落) 之前的细胞间粘性结构的蛋白水解中发挥作用。编码的蛋白质可能在癌症侵袭和转移中发挥作用，并且该基因的表达增加与多种类型癌症的不良预后和进展有关。该基因的多态性可能在特应性皮炎的发展中起作用。已经观察到该基因编码多种同种型的选择性剪接转录变体，它是位于 19 号染色体基因簇中的 15 个激肽释放酶亚家族成员之一。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the Kallikrein subfamily of serine proteases. These Enzymes have diverse physiological functions and many Kallikrein genes are biomarkers for Cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in Cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of Cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen Kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

KLK7 基因产物(4)

mRNA	Protein	Name
NM_001207053.2	NP_001193982.1	kallikrein-7 isoform 2
NM_001243126.1	NP_001230055.1	kallikrein-7 isoform 3
NM_005046.4	NP_005037.1	kallikrein-7 isoform 1 preproprotein
NM_139277.2	NP_644806.1	kallikrein-7 isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables peptidase activity	IMP IMP: 通过突变表型推断	17012259	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of antibacterial peptide production	IMP IMP: 通过突变表型推断	17012259	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in epidermal lamellar body	IDA IDA: 通过直接分析推断	15675955	GOA
located in extracellular space	IMP IMP: 通过突变表型推断	17012259	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLK7 蛋白结构

Trypsin

0
100
200
253 a.a.

蛋白主名

其他名称

kallikrein-7

kallikrein 7 (chymotryptic, stratum corneum)

重组 KLK7 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70163	Kallikrein-7 Protein, Human (HEK293, His, solution)	AAH32005 (E23-H252)	≥95%
HY-P76466	Kallikrein-7 Protein, Human (HEK293, His)	NP_005037.1 (E23-R253)	≥95%

关联疾病

疾病名称

别名

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Occupational Dermatitis

Dermatitis, Occupational	Occupational Allergic Contact Dermatitis
Occupational Eczema

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Psoriasis

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Ichthyosis Vulgaris

Ichthyosis Simplex	Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis	Fish Scale Disease
VI	Ichthyoses
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P4669	LM-030	Inhibitor	/	否
HY-RS07385	KLK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KLK7	RGD	RGD:1306420
Felis catus	KLK7	VGNC	VGNC:67967
Mus musculus	KLK7	MGD	MGI:1346336
Macaca mulatta	KLK7	VGNC	VGNC:74193
Bos taurus	KLK7	VGNC	VGNC:30681
Others	KLK7	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLK7 - kallikrein related peptidase 7 Gene

关于 KLK7

功能概要

KLK7 基因产物(4)

KLK7 蛋白结构

重组 KLK7 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

KLK7 - kallikrein related peptidase 7 Gene

关于 KLK7

功能概要

KLK7 基因产物(4)

KLK7 蛋白结构

重组 KLK7 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z