2. Gene
  3. GPR108 - G protein-coupled receptor 108 Gene

GPR108 - G protein-coupled receptor 108 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 108

种属: Homo sapiens

同用名: LUSTR2

基因 ID: 56927 | 基因类型: protein coding

关于 GPR108

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,729,914-6,737,580 (from NCBI)

This gene has 17 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 21.4), duodenum (RPKM 17.0) and 25 other tissues.

功能概要

预计参与 toll 样受体信号通路的负调控。位于跨高尔基网络。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in negative regulation of Toll-like Receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

GPR108 基因产物(17)

mRNA Protein Name
NM_001080452.2 NP_001073921.1 protein GPR108 isoform 1 precursor
NM_001394714.1 NP_001381643.1 protein GPR108 isoform 2
NM_001394715.1 NP_001381644.1 protein GPR108 isoform 2
NM_001394716.1 NP_001381645.1 protein GPR108 isoform 2
NM_001394717.1 NP_001381646.1 protein GPR108 isoform 3 precursor
NM_001394718.1 NP_001381647.1 protein GPR108 isoform 4 precursor
NM_001394719.1 NP_001381648.1 protein GPR108 isoform 5 precursor
NM_001394720.1 NP_001381649.1 protein GPR108 isoform 6
NM_001394721.1 NP_001381650.1 protein GPR108 isoform 7
NM_001394722.1 NP_001381651.1 protein GPR108 isoform 8
NM_001394723.1 NP_001381652.1 protein GPR108 isoform 9 precursor
NM_001394724.1 NP_001381653.1 protein GPR108 isoform 10
NM_001394725.1 NP_001381654.1 protein GPR108 isoform 11
NM_001394726.1 NP_001381655.1 protein GPR108 isoform 11
NM_001394727.1 NP_001381656.1 protein GPR108 isoform 12
NM_001394728.1 NP_001381657.1 protein GPR108 isoform 13
NM_020171.2 NP_064556.1 protein GPR108 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
32280726 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
31784416 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR108 蛋白结构

Lung_7-TM_R

Lung_7-TM_R: Lung seven transmembrane receptor (215 - 503)

  • 0
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  • 500
  • 543 a.a.
蛋白主名 其他名称

protein GPR108

lung seven transmembrane receptor 2

GPR108 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GPR108 Q9NPR9 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra GPR108 Q9NPR9 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra GPR108 Q9NPR9 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra GPR108 Q9NPR9 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra GPR108 Q9NPR9 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra GPR108 Q9NPR9 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 MTERF3 Homo sapiens Q96E29
Y2H Array
32296183
Intra GPR108 Q9NPR9 MTERF3 Homo sapiens Q96E29
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra GPR108 Q9NPR9 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Periosteal Chondrosarcoma

Juxtacortical Chondrosarcoma
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

Van Der Knaap Disease

Leukoencephalopathy With Swelling And Cysts

MLC1

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

Lvm

Vl

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1

Megalencephalic Leukoencephalopathy With Subcortical Cysts
Enchondromatosis, Multiple, Ollier Type

Ollier Disease

Enchondromatosis

Dyschondroplasia

Osteochondromatosis

Multiple Cartilaginous Enchondroses

Multiple Enchondromatosis

Enchondromatosis With Haemangiomata

Enchondromatosis, Multiple

Kast'S Syndrome

Ollier'S Syndrome

Enchondromatosis Multiple

ENCHOM

Maffucci Disease

Olliers Disease

Hereditary Multiple Exostoses

Chondromatosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05651 GPR108 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPR108 VGNC VGNC:29545
Canis familiaris GPR108 VGNC VGNC:41393
Felis catus GPR108 VGNC VGNC:62671
Mus musculus GPR108 MGD MGI:1925558
Rattus norvegicus GPR108 RGD RGD:735149
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